Other tumors
Malignant fibrous histiocytoma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 8 March 2018, last major update February 2014

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Malignant fibrous histiocytoma spleen

Cite this page: Shankar, V. Malignant fibrous histiocytoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenMFH.html. Accessed December 17th, 2018.
Definition / general
  • Malignant fibrous histiocytoma (MFH) is a soft tissue sarcoma mainly occurring in soft tissue
  • Splenic location is extremely rare
  • Very few cases reported
  • Ages 40 - 60 years with male predominance
Clinical features
  • Abdominal pain, splenomegaly, weight loss and fever are the prominent features in 70% of patients
  • Rarely patients present with acute abdomen or distant metastasis
  • Poor outcome if metastatic disease
Radiology images

Images hosted on other servers:

Hepatic cyst with splenic MFH

Case reports
  • Splenectomy, including laparoscopic splenectomy, with negative margins is treatment of choice
  • Chemo and radiotherapy for patients with metastasis
Gross description
  • Infilrative gray-white areas of varying size with necrosis
Gross images

Images hosted on other servers:

11 cm mass with necrosis

Microscopic (histologic) description
  • Of 5 histologic types (storiform - pleomorphic, myxoid, inflammatory, giant cell and angiomatoid), only storiform, pleomorphic and inflammatory variants have been reported in spleen
  • Multinucleated giant cells, foam cells and inflammatory cells can be seen
  • Frequent mitotic figures
Microscopic (histologic) images

Images hosted on other servers:

Various images

Vimentin and CD68