Spleen
Other tumors
Undifferentiated pleomorphic sarcoma


Topic Completed: 1 February 2014

Minor changes: 31 December 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Malignant fibrous histiocytoma spleen

Vijay Shankar, M.D.
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Cite this page: Shankar V. Undifferentiated pleomorphic sarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenMFH.html. Accessed May 27th, 2020.
Definition / general
  • Soft tissue sarcoma mainly occurring in soft tissue
  • Splenic location is extremely rare
Epidemiology
  • Very few cases reported
  • Ages 40 - 60 years with male predominance
Clinical features
  • Abdominal pain, splenomegaly, weight loss and fever are the prominent features in 70% of patients
  • Rarely patients present with acute abdomen or distant metastasis
  • Poor outcome if metastatic disease
Radiology images

Images hosted on other servers:

Hepatic cyst with splenic MFH

Case reports
Treatment
  • Splenectomy, including laparoscopic splenectomy, with negative margins is treatment of choice
  • Chemo and radiotherapy for patients with metastasis
Gross description
  • Infilrative gray-white areas of varying size with necrosis
Gross images

Images hosted on other servers:

11 cm mass with necrosis

Microscopic (histologic) description
  • Of 5 histologic types (storiform - pleomorphic, myxoid, inflammatory, giant cell and angiomatoid), only storiform, pleomorphic and inflammatory variants have been reported in spleen
  • Multinucleated giant cells, foam cells and inflammatory cells can be seen
  • Frequent mitotic figures
Microscopic (histologic) images

Images hosted on other servers:

Various images

Vimentin and CD68

CD68

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