Other nonneoplastic disorders
Thrombotic thrombocytopenic purpura

Author: Jaleh Mansouri, M.D. (see Authors page)

Revised: 2 March 2018, last major update October 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Thrombotic thrombocytopenic purpura spleen
Cite this page: Mansouri, J. Thrombotic thrombocytopenic purpura. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenTTP.html. Accessed July 17th, 2018.
Definition / general
  • Often associated with splenomegaly
Case reports
  • Newborn with acute respiratory distress, marked jaundice and whole body purpuric rash (Case of the Week #403)
Microscopic (histologic) description
  • Thrombi in arteries and arterioles without inflammation (90%)
  • Also PAS+, diastase resistant hyaline subendothelial deposits of platelet and platelet related material (100%), secondary germinal centers (67%), periarteriolar concentric fibrosis (58%), hemosiderin laden macrophages (92%), hemophagocytosis (83%), extramedullary hematopoiesis (42%)
  • No blood lakes, no microaneurysms, no infarcts (Am J Surg Pathol 1990;14:223)
Peripheral smear images

Images hosted on PathOut server:

Case of the Week #403:

Numerous schistocytes and nucleated RBCs with extremely low platelets on peripheral smear