Spleen
Other non-neoplastic disorders
Thrombotic thrombocytopenic purpura

Authors: Jaleh Mansouri, M.D. (see Authors page)

Revised: 4 October 2016, last major update October 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: thrombotic thrombocytopenic purpura[title] spleen
Cite this page: Thrombotic thrombocytopenic purpura. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenTTP.html. Accessed December 4th, 2016.
Definition / General
  • Often associated with splenomegaly
Case Reports
  • Newborn with acute respiratory distress, marked jaundice and whole body purpuric rash (Case of the Week #403)
Micro Description
  • Thrombi in arteries and arterioles without inflammation (90%)
  • Also PAS+, diastase resistant hyaline subendothelial deposits of platelet and platelet-related material (100%), secondary germinal centers (67%), periarteriolar concentric fibrosis (58%), hemosiderin laden macrophages (92%), hemophagocytosis (83%), extramedullary hematopoiesis (42%)
  • No blood lakes, no microaneurysms, no infarcts (Am J Surg Pathol 1990;14:223)
Micro Images

Images hosted on PathOut server:

Case of the Week #403:

Numerous schistocytes and nucleated RBCs with extremely low platelets on peripheral smear