Other non-neoplastic disorders
Thrombotic thrombocytopenic purpura
Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Often associated with splenomegaly
- Thrombi in arteries and arterioles without inflammation (90%)
- Also PAS+, diastase resistant hyaline subendothelial deposits of platelet and platelet-related material (100%), secondary germinal centers (67%), periarteriolar concentric fibrosis (58%), hemosiderin laden macrophages (92%), hemophagocytosis (83%), extramedullary hematopoiesis (42%)
- No blood lakes, no microaneurysms, no infarcts (Am J Surg Pathol 1990;14:223)
End of Spleen > Other non-neoplastic disorders > Thrombotic thrombocytopenic purpura
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