Lymph nodes & spleen, nonlymphoma
Spleen-other nonneoplastic disorders

Topic Completed: 1 October 2012

Minor changes: 29 September 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Amyloidosis[TI] spleen[TI]

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Cite this page: Mansouri J. Amyloidosis. website. Accessed November 30th, 2020.
Definition / general
  • Usually secondary; rarely localized splenic nodules
  • Even with diffuse involvement, spleen may still retain "pitting" function that prevents appearance of Howell-Jolly bodies in peripheral blood smears (Arch Pathol Lab Med 1995;119:252)
  • Rarely can result in splenic rupture (Am J Hematol 2003;74:131)
Case reports
Gross description
  • Firm and waxy consistency
Microscopic (histologic) description
  • Deposition of pink amorphous material (amyloid) limited either to germinal follicles (sago spleen) or splenic sinusoids and surrounding connective tissue (lardaceous spleen)
Positive stains
  • Congo red with characteristic birefringence (apple green)
Differential diagnosis
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