Spleen
Hematogenous neoplasms
Castleman disease


Topic Completed: 1 January 2013

Revised: 18 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Castleman disease spleen

Jaleh Mansouri, M.D., M.P.H.
Page views in 2018: 498
Page views in 2019 to date: 188
Cite this page: Mansouri J. Castleman disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleencastleman.html. Accessed June 24th, 2019.
Definition / general
  • Also called angiofollicular lymph node hyperplasia
  • Usually no prominent splenomegaly
Microscopic (histologic) description
  • Usually plasma cell type with white pulp hyperplasia and prominent plasmacytosis (Am J Surg Pathol 1988;12:176)
  • Also hyaline vascular type with white pulp hyperplasia and numerous atrophic and hyaline vascular germinal centers, only rare plasma cells
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