Hematogenous neoplasms
Castleman disease

Author: Jaleh Mansouri, M.D. (see Authors page)

Revised: 2 March 2018, last major update January 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Castleman disease spleen

Cite this page: Mansouri, J. Castleman disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleencastleman.html. Accessed March 22nd, 2018.
Definition / general
  • Also called angiofollicular lymph node hyperplasia
  • Usually no prominent splenomegaly
Microscopic (histologic) description
  • Usually plasma cell type with white pulp hyperplasia and prominent plasmacytosis (Am J Surg Pathol 1988;12:176)
  • Also hyaline vascular type with white pulp hyperplasia and numerous atrophic and hyaline vascular germinal centers, only rare plasma cells