Hematogenous neoplasms
Chronic myelogenous leukemia

Topic Completed: 1 January 2013

Revised: 18 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Chronic myelogenous leukemia[TI] spleen

See also: Chronic myeloid neoplasms chapter

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Cite this page: Mansouri J. Chronic myelogenous leukemia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleencml.html. Accessed November 19th, 2019.
Gross description
  • Large, dark red, diffuse involvement with no identifiable Malpighian follicles; often infarcts
Microscopic (histologic) description
  • Polymorphous infiltrate of myeloid cells in all stages of differentiation
  • Mainly affects splenic red pulp cords and sinuses, obliterates white pulp
  • Rarely blastic transformation (Richter syndrome)
Differential diagnosis
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