Hematogenous neoplasms
Chronic myelogenous leukemia

Author: Jaleh Mansouri, M.D. (see Authors page)

Revised: 2 March 2018, last major update January 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Chronic myelogenous leukemia[TI] spleen

See also: Chronic myeloid neoplasms chapter
Cite this page: Mansouri, J. Chronic myelogenous leukemia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleencml.html. Accessed August 17th, 2018.
Gross description
  • Large, dark red, diffuse involvement with no identifiable Malpighian follicles; often infarcts
Microscopic (histologic) description
  • Polymorphous infiltrate of myeloid cells in all stages of differentiation
  • Mainly affects splenic red pulp cords and sinuses, obliterates white pulp
  • Rarely blastic transformation (Richter syndrome)
Differential diagnosis