Chronic myelogenous leukemia
Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Large, dark red, diffuse involvement with no identifiable malpighian follicles; often infarcts
- Polymorphous infiltrate of myeloid cells in all stages of differentiation
- Mainly affects splenic red pulp cords and sinuses, obliterates white pulp
- Rarely blastic transformation (Richter's syndrome)
- Naphthol-AS-D chloroacetate esterase stain, myeloperoxidase, CD33, CD34, CD68, CD117
End of Spleen > Hematogenous neoplasms > Chronic myelogenous leukemia
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