Other tumors
Ectopic adrenal myelolipoma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 8 March 2018, last major update January 2014

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Ectopic adrenal myelolipoma

Cite this page: Shankar, V. Ectopic adrenal myelolipoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenectopicadrenalmyelolipoma.html. Accessed May 21st, 2018.
Definition / general
  • Myelolipoma is rare benign tumor of mature lipomatous and hemopoietic tissue, mature or immature myeloid, erythroid and megakaryocytic cells; more common in adrenal gland
  • Rarely part of generalized myelolipoma
  • Can occur in any age group
  • May be due to misplaced myeloid cells during embryogenesis, followed by hyperplasia
Clinical features
  • Usually an incidental finding
  • Rarely presents with symptoms, usually due to large size or abdominal pain
Radiology images

Images hosted on other servers:

Large well circumscribed soft tissue masses

Intrasplenic myelolipoma

Case reports
  • Surgical excision
Gross description
  • Yellow-tan to red-tan, circumscribed mass surrounded by rim of dark red splenic parenchyma
  • Color of cut surface depends on relative distributions of fat, blood and blood forming cells
Gross images

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Horizontal section of spleen

Resected extra-adrenal myelolipoma

Microscopic (histologic) description
  • Well encapsulated foci of extramedullary hematopoesis that also contain fat, smooth muscle, bone marrow cells
Microscopic (histologic) images

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Adipocytes and bone marrow elements