Epithelial cyst

Author: Jaleh Mansouri, M.D. (see Authors page)

Revised: 1 March 2018, last major update October 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Epithelial cyst[TIAB] spleen

Cite this page: Mansouri, J. Epithelial cyst. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenepithelialcysts.html. Accessed March 24th, 2018.
Definition / general
  • Usually children or young adults
  • Solitary or multiple; may be associated with accessory spleen
  • May mimic mucinous cystic neoplasm if in intrapancreatic accessory spleen
  • Called "epithelioid" / "epidermoid" if squamous lining
  • Origin unknown; may derive from metaplasia in mesothelial cysts (Am J Surg Pathol 1988;12:275)
  • Often large and requires splenectomy
Case reports
  • 62 year old man with epidermoid cyst in intrapancreatic accessory spleen (JOP 2011;12:279)
Gross description
  • Glistening inner surface with marked trabeculation
Microscopic (histologic) description
  • Lined by squamous, columnar, cuboidal or mesothelial-like epithelium
  • No skin adnexae
  • Rarely mucinous and associated with pseudomyxoma peritonei
Microscopic (histologic) images

Images hosted on other servers:

Multiple splenic
cysts with
stratified squamous

Cyst lining is CEA+

Positive stains
Differential diagnosis