Lymphoma & related disorders
Splenic hematogenous neoplasms
Fibroblastic reticulum cell tumor

Topic Completed: 1 January 2013

Minor changes: 1 April 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Fibroblastic reticulum cell tumor spleen

Page views in 2019: 315
Page views in 2020 to date: 212
Cite this page: Mansouri J. Fibroblastic reticulum cell tumor. website. Accessed August 12th, 2020.
Definition / general
  • Very rare
  • Dendritic / reticular cells are immune system cells, subdivided into follicular dendritic cells, interdigitating dendritic cells (and closely related Langerhans cells) and fibroblastic reticulum cells
  • Fibroblastic reticulum cells are stromal support cells located in the parafollicular and deep cortex of lymph nodes and in extrafollicular areas of spleen and tonsils
Case reports
  • 61 year old woman with multiple hepatic lesions 2 years after splenectomy for tumor (Hum Pathol 2003;34:954)
Microscopic (histologic) description
  • Whorled pattern of oval and spindle cells in collagenous background; also lymphocytes and plasma cells
Positive stains
Negative stains
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