Spleen
Hematogenous neoplasms
Fibroblastic reticulum cell tumor


Topic Completed: 1 January 2013

Revised: 18 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Fibroblastic reticulum cell tumor spleen

Jaleh Mansouri, M.D., M.P.H.
Page views in 2018: 285
Page views in 2019 to date: 137
Cite this page: Mansouri J. Fibroblastic reticulum cell tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenfibroblasticreticulumcelltumor.html. Accessed June 24th, 2019.
Definition / general
  • Very rare
  • Dendritic / reticular cells are immune system cells, subdivided into follicular dendritic cells, interdigitating dendritic cells (and closely related Langerhans cells) and fibroblastic reticulum cells
  • Fibroblastic reticulum cells are stromal support cells located in the parafollicular and deep cortex of lymph nodes and in extrafollicular areas of spleen and tonsils
Case reports
  • 61 year old woman with multiple hepatic lesions 2 years after splenectomy for tumor (Hum Pathol 2003;34:954)
Microscopic (histologic) description
  • Whorled pattern of oval and spindle cells in collagenous background; also lymphocytes and plasma cells
Positive stains
Negative stains
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