Infectious / inflammatory disorders
Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 6 December 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Histiocytic cells characterized by foamy cytoplasm, located in splenic red pulp
- Found in: chronic granulomatous disease, exogenous mineral oil ingestion (part of packaging of foodstuffs in North America, also seen in liver and abdominal lymph nodes), hyperlipidemia, immune thrombocytopenic purpura, Niemann-Pick disease, sea-blue histiocyte syndrome, Tay-Sachs disease, thalassemia
- Contain foamy vacuolated cytoplasm with accumulation of phospholipids and sphingomyelin, react with fat stains, Periodic acid-Schiff with diastase (PAS-D)
- Found in Gaucher's disease, contain fibrillar cytoplasm with accumulation of glucocerebrosidase, stain positively for iron, nonspecific esterase, tartrate resistant acid phosphatase, PAS (weak)
- Negative for phospholipids
- Resemble Gaucher cells but have normal enzyme activity
- Seen in various conditions including chronic mylogenous leukemia (CML)
End of Spleen > Infectious / inflammatory disorders > Foamy macrophages
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