Hematogenous neoplasms
Follicular dendritic cell tumor

Author: Jaleh Mansouri, M.D. (see Authors page)

Revised: 6 March 2018, last major update January 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Follicular dendritic cell tumor spleen

Cite this page: Mansouri, J. Follicular dendritic cell tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenfolliculardendriticcelltumor.html. Accessed August 17th, 2018.
Definition / general
  • Rare; usually affects lymph nodes and extranodal sites

Inflammatory pseudotumor-like variant:
  • Usually women, frequently with systemic symptoms
  • Indolent behavior
  • Localizes in liver, spleen
  • Associated with EBV
  • Prominent lymphoplasmacytic infiltration (Am J Surg Pathol 2001;25:721)
Clinical features
Case reports
  • 50 year old woman with follicular dendritic cell sarcoma of spleen and associated diffuse large B cell lymphoma (Hum Pathol 2008;39:776)
Microscopic (histologic) description
  • Fascicles, sheets, storiform or whorled patterns of oval and spindled cells
  • May have lymphocytes and plasma cells
  • May mimic inflammatory pseudotumor but usually demonstrates more prominent nuclear atypia with positive CD21 and CD35 immunostaining
Microscopic (histologic) images

Images hosted on other servers:



Lymph node

Tonsil: CD21

Lymph node: CD35

Positive stains
Negative stains
Differential diagnosis