Spleen
Hematogenous neoplasms
Follicular lymphoma


Topic Completed: 1 January 2013

Revised: 18 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Follicular lymphoma[TIAB] spleen

Jaleh Mansouri, M.D., M.P.H.
Page views in 2018: 835
Page views in 2019 to date: 453
Cite this page: Mansouri J. Follicular lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenfollicularlymphoma.html. Accessed June 24th, 2019.
Definition / general
  • Usually also involves other lymphoid sites besides spleen
  • Spleen may be clinically normal but still involved by lymphoma in most white pulp segments
Gross description
  • Extensive white pulp nodules
Microscopic (histologic) description
  • Relatively homogenous, multicentric involvement of almost all white pulp areas, usually with centrocytes
  • No tingible body macrophages in neoplastic areas, no / reduced mantle zone, no associated plasmacytosis in red pulp
  • May have conspicuous marginal zone
  • Some cases may show architectural preservation with a predominant intrafollicular growth pattern (in situ follicular lymphoma, J Clin Path 2009;131:656)
Microscopic (histologic) images

Images hosted on other servers:

Histologic features

Immuno-histochemical analysis

Positive stains
  • BCL2 in germinal centers
Molecular / cytogenetics description
  • t(14;18) usually present
Differential diagnosis
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