Hematogenous neoplasms
Follicular lymphoma

Author: Jaleh Mansouri, M.D. (see Authors page)

Revised: 5 March 2018, last major update January 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Follicular lymphoma[TIAB] spleen

Cite this page: Mansouri, J. Follicular lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenfollicularlymphoma.html. Accessed March 24th, 2018.
Definition / general
  • Usually also involves other lymphoid sites besides spleen
  • Spleen may be clinically normal but still involved by lymphoma in most white pulp segments
Gross description
  • Extensive white pulp nodules
Microscopic (histologic) description
  • Relatively homogenous, multicentric involvement of almost all white pulp areas, usually with centrocytes
  • No tingible body macrophages in neoplastic areas, no / reduced mantle zone, no associated plasmacytosis in red pulp
  • May have conspicuous marginal zone
  • Some cases may show architectural preservation with a predominant intrafollicular growth pattern (in situ follicular lymphoma, J Clin Path 2009;131:656)
Microscopic (histologic) images

Images hosted on other servers:

Histologic features

Immuno-histochemical analysis

Positive stains
  • BCL2 in germinal centers
Molecular / cytogenetics description
  • t(14;18) usually present
Differential diagnosis