Infectious / inflammatory disorders
Granulomatous inflammation

Author: Jaleh Mansouri, M.D. (see Authors page)

Revised: 1 March 2018, last major update October 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Granulomatous inflammation[TI] spleen

Table of Contents
Definition / general | Treatment
Cite this page: Mansouri, J. Granulomatous inflammation. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleengranulomatousinflammation.html. Accessed March 22nd, 2018.
Definition / general
  • Common in splenectomy specimens
  • Either:
    1. Large active granulomas with epithelioid and Langhans giant cells, with or without central necrosis
    2. Widespread small, sarcoid-like epithelioid granulomas with rare giant cells and no necrosis
    3. Inactive granulomas with fibrosis and calcification
  • Granulomas usually associated with systemic disease involving liver, bone marrow and lymph nodes; also chronic uremia, IgA deficiency, infectious mononucleosis
  • Granulomas may be present in hairy cell leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, although granuloma itself does not mean spleen is involved by tumor (Arch Pathol Lab Med 1977;101:518)
  • Active granulomas: in adults, associated with fever, weight loss, hepatosplenomegaly and hypersplenism
  • Inactive granulomas: associated with histoplasmosis
  • Splenectomy for symptoms of hypersplenism