Lymph nodes & spleen, nonlymphoid
Spleen-vascular tumors

Topic Completed: 1 October 2013

Minor changes: 28 July 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Hamartoma[TI] spleen

Vijay Shankar, M.D.
Page views in 2019: 2,301
Page views in 2020 to date: 1,256
Cite this page: Shankar V. Hamartoma. website. Accessed August 12th, 2020.
Definition / general
  • Rare benign tumor, usually congenital, composed of aberrant mixture of normal splenic tissue
  • Nodular lesion of variable size, derived from splenic sinus lining cells
  • Also called splenoma, splenoadenoma, nodular hyperplasia of the spleen
  • All age groups, equal sex preponderance
Clinical features
  • Usually an incidental finding
  • Can present with pain, palpable mass or spontaneous rupture
  • May be associated with tuberous sclerosis, Wiskott-Aldrich-like syndrome, hypersplenism (thrombocytopenia, anemia, pancytopenia)
  • Rarely associated with malignant hematologic conditions
Radiology images

Images hosted on other servers:

Hypodense mass of the spleen

Homogenous and hypoechoic mass

Isointense mass (arrows)

Case reports
  • Splenectomy (complete or partial; laparoscopic or hand assisted laparoscopic)
Gross description
  • Circumscribed nodular lesion, dark red, compressing splenic parenchyma, ranging from a few mm to several cm
  • May be single or multiple
Gross images

Images hosted on other servers:

Nodule of increased stiffness

Resected spleen

Varying sizes of vascular spaces

Microscopic (histologic) description
  • Either follicular or pulpous and fibrous
  • Well circumscribed lesion with disorganized blood vessels of varying sizes intermingled with splenic red pulp element
  • Also entrapped adipocytes, focal extramedullary hematopoiesis
Microscopic (histologic) images

Images hosted on other servers:

Red pulp splenic sinusoidal structure

Splenic red pulp element

Entrapped clusters of adipocytes

Nonencapsulated nodule

Positive for reticulin

Positive stains
Electron microscopy images

Images hosted on other servers:

Tall lining cells

Molecular / cytogenetics description
Back to top