Vascular tumors

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 8 March 2018, last major update October 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Hemangioendothelioma spleen

Cite this page: Shankar, V. Hemangioendothelioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenhemangioendothelioma.html. Accessed March 22nd, 2018.
Definition / general
  • Very rare, low grade malignant primary vascular tumor of spleen, with intermediate biologic behavior between hemangioma and angiosarcoma
  • Often young, no gender predilection
Clinical features
  • Vague pain, palpable mass and fatigue
  • Functional hyposplenism, spontaneous or traumatic rupture can occur
  • Rarely mild anemia, indirect hyperbilirubinemia
  • Based on radiological examination and histopathological confirmation
Radiology description
  • Ultrasound: hypoechoic mass distinct from surrounding spleen
  • CT: low attenuation mass
  • MRI: heterogenous solid lesion
Radiology images

Images hosted on other servers:

Large protruding cystic mass

Hypodense lesions

Case reports
  • Splenectomy
Gross description
  • Well separated lesions, solitary or multiple of variable size
Gross images

Images hosted on other servers:

Multicystic lesion

Microscopic (histologic) description
  • More cellular than hemangioma, less atypical than angiosarcoma
  • Epithelioid or spindled
  • Ill defined vascular spaces lined by cells with mild or moderate atypia
  • Low mitotic index
Microscopic (histologic) images

Images hosted on other servers:

Uniform population of spindle cells

Composite hemangio-endothelioma

Abundant pale eosinophilic cytoplasm

Vascular channels lined by plump epithelial cells

Positive stains
Differential diagnosis