Hematogenous neoplasms
Hepatosplenic alpha / beta T cell lymphoma

Author: Jaleh Mansouri, M.D. (see Authors page)

Revised: 5 March 2018, last major update March 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Hepatosplenic alpha / beta T cell lymphoma

Cite this page: Mansouri, J. Hepatosplenic alpha / beta T cell lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenhepatoalpha.html. Accessed August 20th, 2018.
Definition / general
  • Rare; < 50 cases reported
  • Similar clinical presentation as hepatosplenic gamma / delta T cell lymphoma; also aggressive
  • 79% female (although some reports indicate male predominance), wider age distribution than gamma / delta (some children, some age 50+ years)
  • Usually no significant nodal involvement
  • Peripheral blood involvement late in disease; may have blastic transformation
Case reports
Microscopic (histologic) description
  • Involves splenic red pulp, hepatic sinusoids and periportal areas, interstitial bone marrow
  • Medium size tumor cells with scant to moderate cytoplasm (occasionally abundant), round / oval nuclei, inconspicuous nucleoli, irregular chromatin with nucleoli
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Molecular / cytogenetics description
  • T cell receptor rearrangements, some with isochromosome 7q