Hematogenous neoplasms
Hepatosplenic alpha / beta T cell lymphoma

Topic Completed: 1 March 2013

Revised: 18 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Hepatosplenic alpha / beta T cell lymphoma

Page views in 2018: 171
Page views in 2019 to date: 194
Cite this page: Mansouri J. Hepatosplenic alpha / beta T cell lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenhepatoalpha.html. Accessed December 11th, 2019.
Definition / general
  • Rare; < 50 cases reported
  • Similar clinical presentation as hepatosplenic gamma / delta T cell lymphoma; also aggressive
  • 79% female (although some reports indicate male predominance), wider age distribution than gamma / delta (some children, some age 50+ years)
  • Usually no significant nodal involvement
  • Peripheral blood involvement late in disease; may have blastic transformation
Case reports
Microscopic (histologic) description
  • Involves splenic red pulp, hepatic sinusoids and periportal areas, interstitial bone marrow
  • Medium size tumor cells with scant to moderate cytoplasm (occasionally abundant), round / oval nuclei, inconspicuous nucleoli, irregular chromatin with nucleoli
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Molecular / cytogenetics description
  • T cell receptor rearrangements, some with isochromosome 7q
Back to top