Lymphoma & related disorders
Splenic hematogenous neoplasms
Hepatosplenic gamma / delta

Topic Completed: 1 March 2013

Minor changes: 5 July 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Hepatosplenic gamma / delta T cell lymphoma

Page views in 2019: 383
Page views in 2020 to date: 222
Cite this page: Mansouri J. Hepatosplenic gamma / delta. website. Accessed August 6th, 2020.
Definition / general
Gross description
  • Very large spleen with uniform cut surface and no identifiable Malpighian follicles
Microscopic (histologic) description
  • Lymphoid infiltrates in splenic red pulp composed of medium sized tumor cells with scant to moderate cytoplasm, round / oval nuclei with possible folds, slightly dispersed chromatin, inconspicuous nucleoli
  • Liver and bone marrow tumor cells have intrasinusoidal distribution
Microscopic (histologic) images

Images hosted on other servers:

Primary cutaneous



Other γδ T cell lymphomas

T cell lymphoma, TCR silent

Positive stains
Negative stains
  • CD4, CD5, variable CD8, alpha / beta T cell receptor
Molecular / cytogenetics description
Differential diagnosis
  • Hairy cell leukemia: blood lakes, negative for T cell markers, no T cell receptor rearrangement
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