Hematogenous neoplasms
Hepatosplenic gamma / delta T cell lymphoma

Topic Completed: 1 March 2013

Revised: 18 March 2019

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PubMed Search: Hepatosplenic gamma / delta T cell lymphoma

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Cite this page: Mansouri J. Hepatosplenic gamma / delta T cell lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenhepatogamma.html. Accessed October 18th, 2019.
Definition / general
Gross description
  • Very large spleen with uniform cut surface and no identifiable Malpighian follicles
Microscopic (histologic) description
  • Lymphoid infiltrates in splenic red pulp composed of medium sized tumor cells with scant to moderate cytoplasm, round / oval nuclei with possible folds, slightly dispersed chromatin, inconspicuous nucleoli
  • Liver and bone marrow tumor cells have intrasinusoidal distribution
Microscopic (histologic) images

Images hosted on other servers:

Primary cutaneous



Other γδ T cell lymphomas

T cell lymphoma, TCR silent

Positive stains
Negative stains
  • CD4, CD5, variable CD8, alpha / beta T cell receptor
Molecular / cytogenetics description
Differential diagnosis
  • Hairy cell leukemia: blood lakes, negative for T cell markers, no T cell receptor rearrangement
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