Hematogenous neoplasms
Hepatosplenic gamma / delta T cell lymphoma

Author: Jaleh Mansouri, M.D. (see Authors page)

Revised: 5 March 2018, last major update March 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Hepatosplenic gamma / delta T cell lymphoma

Cite this page: Mansouri, J. Hepatosplenic gamma / delta T cell lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenhepatogamma.html. Accessed May 21st, 2018.
Definition / general
Gross description
  • Very large spleen with uniform cut surface and no identifiable Malpighian follicles
Microscopic (histologic) description
  • Lymphoid infiltrates in splenic red pulp composed of medium sized tumor cells with scant to moderate cytoplasm, round / oval nuclei with possible folds, slightly dispersed chromatin, inconspicuous nucleoli
  • Liver and bone marrow tumor cells have intrasinusoidal distribution
Microscopic (histologic) images

Images hosted on other servers:

Primary cutaneous



Other γδ T cell lymphomas

T cell lymphoma, TCR silent

Positive stains
Negative stains
  • CD4, CD5, variable CD8, alpha / beta T cell receptor
Molecular / cytogenetics description
Differential diagnosis
  • Hairy cell leukemia: blood lakes, negative for T cell markers, no T cell receptor rearrangement