Hematogenous neoplasms
Histiocytic lymphoma / sarcoma

Topic Completed: 1 March 2013

Revised: 18 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Histiocytic lymphoma[TIAB] OR histiocytic sarcoma[TIAB] spleen

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Cite this page: Mansouri J. Histiocytic lymphoma / sarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenhistiocyticlymphoma.html. Accessed October 21st, 2019.
Definition / general
  • Rare to initially involve the spleen; usually arises in GI tract or skin
  • Must exclude diffuse large B cell or T cell lymphomas, anaplastic large cell lymphomas, acute monocytic leukemia
  • Called malignant histiocytosis if disseminated
  • May arise in mediastinal germ cell tumors
Case reports
Gross images

Images hosted on other servers:

Splenic histiocytic sarcoma

Microscopic (histologic) description
  • Diffuse sinusoidal infiltration of red pulp by neoplastic histiocytes with extension into cords
  • May be multinucleated giant atypical cells
  • Foci of spindled morphology may be seen
  • Often erythrophagocytosis; inconspicuous white pulp
  • No nodules or tumor masses
Microscopic (histologic) images

Images hosted on other servers:

Various images

CD68+, CD163+, lysozyme+

Secondary bone marrow involvement

Electron microscopy description
  • Dilated sinuses lined by large atypical histiocytic cells with abundant lysosomes and prominent erythrophagocytosis
  • No Birbeck granules
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