Spleen
Hematogenous neoplasms
Histiocytic lymphoma / sarcoma

Author: Jaleh Mansouri, M.D. (see Authors page)

Revised: 5 March 2018, last major update March 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Histiocytic lymphoma[TIAB] OR histiocytic sarcoma[TIAB] spleen

Cite this page: Mansouri, J. Histiocytic lymphoma / sarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenhistiocyticlymphoma.html. Accessed August 20th, 2018.
Definition / general
  • Rare to initially involve the spleen; usually arises in GI tract or skin
  • Must exclude diffuse large B cell or T cell lymphomas, anaplastic large cell lymphomas, acute monocytic leukemia
  • Called malignant histiocytosis if disseminated
  • May arise in mediastinal germ cell tumors
Case reports
Gross images

Images hosted on other servers:

Splenic histiocytic sarcoma

Microscopic (histologic) description
  • Diffuse sinusoidal infiltration of red pulp by neoplastic histiocytes with extension into cords
  • May be multinucleated giant atypical cells
  • Foci of spindled morphology may be seen
  • Often erythrophagocytosis; inconspicuous white pulp
  • No nodules or tumor masses
Microscopic (histologic) images

Images hosted on other servers:

Various images

CD68+, CD163+, lysozyme+

Secondary bone marrow involvement

Electron microscopy description
  • Dilated sinuses lined by large atypical histiocytic cells with abundant lysosomes and prominent erythrophagocytosis
  • No Birbeck granules