Hematogenous neoplasms
Hodgkin lymphoma

Topic Completed: 1 March 2013

Minor changes: 1 April 2020

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PubMed Search: Hodgkin lymphoma[TI] spleen

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Cite this page: Mansouri J. Hodgkin lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenhodgkin.html. Accessed May 30th, 2020.
Definition / general
  • Most common site of extranodal involvement is spleen but primary disease in spleen is rare
  • Splenectomy previously was part of staging procedure if low clinical stage; now replaced by radiologic imaging
  • May present with splenic rupture
  • Important to report whether 0 - 4 or 5+ macroscopic nodules present in spleen (affects prognosis)
  • Subclassification not a factor in therapy
Case reports
Gross description
  • One or more multiple nodules, may be only a few millimeters
Microscopic (histologic) description
  • Earliest lesions are in periarterial lymphoid sheath or marginal zones
  • Usually nodular sclerosis subtype
  • May have sarcoid type granulomas even without splenic involvement
  • Reed-Sternberg cells difficult to identify
Microscopic (histologic) images

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