Lymph nodes & spleen, nonlymphoid
Spleen-vascular tumors

Topic Completed: 1 December 2013

Minor changes: 28 July 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Hemangiopericytoma spleen

Vijay Shankar, M.D.
Page views in 2019: 311
Page views in 2020 to date: 699
Cite this page: Shankar V. Hemangiopericytoma. website. Accessed August 12th, 2020.
Definition / general
  • Very rare vascular neoplasm of uncertain biological behavior
  • Primarily affects middle aged adults
  • Males and females are equally affected
Clinical features
  • Usually asymptomatic, can present with splenomegaly
  • Can present with hemoperitoneum due to spontaneous or traumatic rupture
  • CT or MRI, then histopathological confirmation
Radiology images

Images hosted on other servers:

Active bleeding in splenic cystic lesion

Case reports
  • Partial or total splenectomy
Gross description
  • Single or multiple, encapsulated, soft to rubbery
  • Average size is 6.5 cm
Gross images

Images hosted on other servers:

Lobulated, solid, well circumscribed nodules

Microscopic (histologic) description
  • Well developed, branching, thick walled blood vessels surrounded by connective tissue sheath
  • Monotonous cells with moderate to high cellularity
  • Hemorrhagic and cystic degeneration can be seen
  • Rarely manifest as multiple abscesses
Microscopic (histologic) images

Images hosted on other servers:

Dilated sinuous vascular channels (H&E and reticulin)

Positive stains
Molecular / cytogenetics description
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