Other nonneoplastic disorders

Author: Jaleh Mansouri, M.D. (see Authors page)

Revised: 2 March 2018, last major update October 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Hypersplenism[TI] spleen[TIAB] full text[sb]

Table of Contents
Definition / general
Cite this page: Mansouri, J. Hypersplenism. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenhypersplenism.html. Accessed March 24th, 2018.
Definition / general
  • Also called dysplenism
  • Enlarged spleen leads to removal of cellular blood components (some or all), causing thrombocytopenia, neutropenia, hemolytic anemia or pancytopenia
  • Due to disorders (congestive splenomegaly, Gaucher disease, hamartoma, hemangioma, Langerhans cell histiocytosis, leukemia / lymphoma, other conditions diffusely involving red pulp) causing widening of splenic cords with increase in macrophages or connective tissue, causing premature destruction of normal blood components
  • Reactive follicular hyperplasia of white pulp may be present in hypersplenism associated with cytopenias
  • Infectious causes include brucellosis, CMV, Echinococcus, histoplasmosis, infectious mononucleosis, leishmaniasis, malaria, schistosomiasis, syphilis, toxoplasmosis, trypanosomiasis, tuberculosis, typhoid
  • May be due to abnormal cellular blood components (hereditary spherocytosis)