Lymphoma & related disorders
Splenic hematogenous neoplasms
Interdigitating dendritic cell sarcoma

Topic Completed: 1 March 2013

Minor changes: 1 April 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Interdigitating dendritic cell sarcoma spleen

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Cite this page: Mansouri J. Interdigitating dendritic cell sarcoma. website. Accessed August 6th, 2020.
Definition / general
  • Very rare
  • Usually involves lymph nodes but involvement of visceral organs with hepatosplenomegaly may be seen
  • May present with fever and night sweats

Dendritic cells:
  • Includes Langerhans cells, interdigitating dendritic cells, follicular dendritic cells, dermal dendrocytes, indeterminate cells and veiled cells
  • Present in T cell areas of spleen (also lymph node, tonsil, thymus medulla)
  • Stimulate resting T cells to initiate cellular immunity
  • Interdigitating dendritic cell believed to be normal counterpart of neoplastic cells
Case reports
Gross description
  • Markedly enlarged spleen with confluent massive nodules
Microscopic (histologic) description
  • Sheets or fascicles in red pulp, impinging on white pulp, of large cells with voluminous cytoplasm, polylobated or multiple nuclei, dispersed chromatin with clumping along nuclear membranes, often prominent eosinophilic nuclei
  • Also erythrophagocytosis, variable pleomorphism
Positive stains
Negative stains
Electron microscopy description
  • Complex, interdigitating cytoplasmic dendritic processes
  • Scattered lysosomes sometimes seen
  • No Birbeck granules
Differential diagnosis
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