Cite this page: Mansouri J. Lipid histiocytoses. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenlipidhistiocytoses.html. Accessed June 16th, 2019.
Definition / general
- Includes ceroid (sea blue) histiocytosis, chronic myelogenous leukemia, follicular (mineral oil) lipidosis (due to lipid in packaging of food, Hum Pathol 1984;15:724), Gaucher disease and other inherited diseases, hyperlipoproteinemia, immune thrombocytopenic purpura, light chain deposition disease
- Ceroid: benign histiocytes with abundant, foamy, vacuolated cytoplasm due to ingestion of sphingomyelin and other phospholipids
- Sea blue histiocyte syndrome (OMIM: Sea Blue Histiocyte Disease [Accessed 2 March 2018]): autosomal recessive, may be related to adult Niemann-Pick disease (Hum Pathol 1982;13:1115)
Microscopic (histologic) description
- Histiocytes diffusely within splenic cords; may separate the white pulp but don't diminish its size