Vascular tumors
Littoral cell angioma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 8 March 2018, last major update December 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Littoral cell angioma spleen

Cite this page: Shankar, V. Littoral cell angioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenlittoralcellangioma.html. Accessed August 16th, 2018.
Definition / general
  • Express endothelial and histiocyte associated antigens, similar to littoral cells lining venous sinuses of normal spleen
  • Median age: 50 years (range 1 - 77 years), female:male ratio = 5:3
Clinical features
  • 50% present with splenomegaly, hypersplenism associated thrombocytopenia or anemia
  • Almost always benign behavior but associated with Crohn's disease, adenocarcinoma of colon and pancreas
Radiology description
  • Ultrasound findings vary from heterogeneous echotexture without specific nodules to hyperechogenic, hypoechogenic or isoechogenic appearing lesions
  • Computed tomography typically shows multiple hypoattenuating nodules
Case reports
  • Splenectomy
Gross description
  • Minute to large distinct nodules of variable consistency replacing entire spleen
  • Various colors (yellow / brown to red / black / brown) depending on degree of necrosis, cyst formation, thrombi, fibrosis
  • Spongy / cystic
Gross images

Images hosted on other servers:

Multiple nodules

Microscopic (histologic) description
  • Anastomosing monotonous vascular channels resembling splenic sinuses but lined by tall endothelial cells with variable hemophagocytosis
  • Channels have irregular lumina, often papillary projections and cystic spaces
  • Endothelial cells frequently detach into vascular spaces
  • No sclerosis, no atypia
Microscopic (histologic) images

Images hosted on other servers:

Neoplastic sinuses

Tumor and normal spleen

Anastomosing vascular spaces

Papillary projections

Large blood filled cystic spaces

Intracytoplasmic eosinophilic globules

CD31+, CD68+

Positive stains
Negative stains