Hematogenous neoplasms
Lymphoplasmacytic lymphoma

Topic Completed: 1 March 2013

Revised: 18 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Lymphoplasmacytic lymphoma spleen

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Cite this page: Mansouri J. Lymphoplasmacytic lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenlymphoplasmacyticlymphoma.html. Accessed October 13th, 2019.
Definition / general
  • Associated with Waldenström macroglobulinemia with bone marrow involvement, although IgM paraprotein not required for diagnosis of lymphoplasmacytic lymphoma
  • May be associated with hepatitis C in some patients
  • Postulated normal counterpart is postgerminal B cell destined for plasma cell differentiation
  • WHO definition:
    • Morphology below without features of other lymphoma types
    • May have plasmacytic differentiation
    • Serum IgM monoclonal protein present, monotypic B cell tumor negative for CD5, CD10, CD23
Case reports
Microscopic (histologic) description
  • Red and white pulp involvement by small lymphocytes, plasmacytoid lymphocytes, plasma cells
  • Many cells have Russell bodies (intracytoplasmic inclusions) and Dutcher bodies (intranuclear inclusions)
  • May have prominent epithelioid histiocytes
  • No proliferation centers
Microscopic (histologic) images

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Various images

Peripheral smear images

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Lymphoplasmacytoid lymphocyte

Positive stains
  • CD19, CD20, CD22, CD79a, cytoplasmic immunoglobulins such as IgM (plasmacytic cells)
Negative stains
Differential diagnosis
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