Infectious / inflammatory disorders

Topic Completed: 1 October 2012

Minor changes: 18 March 2019

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PubMed Search: Malaria[TI] spleen[TI]

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Cite this page: Mansouri J. Malaria. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenmalaria.html. Accessed May 30th, 2020.
Definition / general
  • May result in splenic rupture, infarction or rarely sudden death, especially with infection by Plasmodium falciparum (Leg Med (Tokyo) 2012;14:111)
Case reports
Microscopic (histologic) description
  • Hallmark finding is vascular congestion with adherence to endothelial wall by parasitized red blood cells, macrophages contain brown malarial pigment, disorganized architecture with loss of marginal zone and ill defined T cell zones (Cell Microbiol 2012;14:343)
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