Hematogenous neoplasms
Mantle cell lymphoma

Author: Jaleh Mansouri, M.D. (see Authors page)

Revised: 6 March 2018, last major update March 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Mantle cell lymphoma[TI] spleen

Cite this page: Mansouri, J. Mantle cell lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenmantlecellymphoma.html. Accessed July 17th, 2018.
Definition / general
  • Aggressive
  • Usually presents with splenomegaly and advanced disease
  • Often with bone marrow involvement; may have marked lymphocytosis mimicking prolymphocytic leukemia
  • Blastoid variant may develop result in splenic rupture
  • Other variants include pleomorphic, small cell and marginal zone-like
  • Postulated normal counterpart is nave pregerminal center B cell of inner mantle zone
Clinical features
Case reports
Microscopic (histologic) description
  • Confluent tumor nodules in white pulp or enlarged lymphocytic coronas surrounding germinal centers
  • Often involvement of red pulp
  • Small cells with irregular, often indented, hyperchromatic nuclei
  • No proliferation centers, no prolymphocytes
  • May have marginal zone-like differentiation, with more abundant, pale staining cytoplasm
Microscopic (histologic) images

Images hosted on other servers:

Expansion of mantle zone

White pulp
expanded by
proliferation of
small lymphocytes

Blastoid variant

Various images

Positive stains
Negative stains
Molecular / cytogenetics description
  • t(11,14)(q13;q32)
Molecular / cytogenetics images

Images hosted on other servers:

Hypothetical models
of two different
molecular subtypes
of MCL

Major aberrant
pathways in MCL
susceptible to
targeted therapies

Multistep model in progression of MCL

FICTION analysis for t(11;14)(q13;q32)