Spleen
Other tumors
Metastases

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 8 March 2018, last major update February 2014

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Metastases[TI] spleen[TI]

Cite this page: Shankar, V. Metastases. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenmetastases.html. Accessed August 17th, 2018.
Definition / general
  • Splenic metastasis is usually associated with extensive metastases - isolated splenic metastasis is rare
Sites
Pathophysiology
  • Metastasis may be rare due to spleen's immunological function
  • Metastases developed by hematogenous, lymphatic or abdominal cavity implantation routes; also direct invasion from lesions in adjacent organs
  • Hematogenous or direct seeding is more common
Clinical features
  • No specific clinical presentation
  • Rarely present with splenic rupture
Diagnosis
  • By radiological examination followed by histopathological confirmation
Radiology description
  • In ultrasonographic examination, the metastatic foci in the spleen may be hyperechoic, hypoechoic or nonechoic
  • In CT, hypodense lesions are seen
Radiology images

Images hosted on other servers:

F-FDG PET images of splenic metastasis

CT images of splenic metastasis

Case reports
Treatment
  • Splenectomy and chemotherapy depending on the primary tumor
Gross description
  • Splenic metastasis can be seen as solitary nodule, multiple nodules or diffuse infiltration or cyst
  • Rarely resembles follicular lymphoma grossly with multiple nodules
Microscopic (histologic) description
Microscopic (histologic) images

Images hosted on other servers:

Parotid gland: carcinoma ex pleomorphic adenoma