Spleen
Other tumors
Mucinous cystadenocarcinoma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 9 March 2018, last major update February 2014

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Mucinous cystadenocarcinoma spleen

Cite this page: Shankar, V. Mucinous cystadenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenmucinouscystadenocarcinoma.html. Accessed August 16th, 2018.
Definition / general
  • Resembles ovarian tumor
  • May arise from invaginated capsular mesothelium of spleen or heterotopic pancreatic or intestinal tissue within the spleen
  • Proposed sequence: congenital or traumatic invagination of splenic capsular mesothelium, followed by cystic dilatation, mucinous metaplasia and very rarely, neoplastic transformation
Clinical features
  • Nonspecific
  • May present with mass or pain in abdomen
  • May be associated with pseudomyxoma peritonei
Radiology description
  • CT scan: multicystic mass with septa
Case reports
  • 21 year old woman with splenic mucinous cystadenocarcinoma arising in heterotopic pancreatic tissue (Tumori 1998;84:606)
  • 66 year old woman with splenic low grade mucinous cystadenocarcinoma resulting in pseudomyxoma peritonei (Med Mol Morphol 2010;43:235)
  • 68 year old woman with splenic mucinous cystadenocarcinoma with KRAS mutation at codon 12 (Dig Dis Sci 1999;44:768)
Gross description
  • Multiple cysts containing large amounts of yellowish, translucent mucinous material
  • Solid areas may be present
  • Walls of the cysts are smooth, gray-white and glistening
  • Peripheral calcification can be seen
Microscopic (histologic) description
  • Splenic parenchyma occupied by large mucinous pools, which may be lined by tall columnar mucinous epithelial cells or mesothelial-like cells
Differential diagnosis
Additional references