Infectious / inflammatory disorders

Author: Jaleh Mansouri, M.D. (see Authors page)

Revised: 1 March 2018, last major update October 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Mycobacteria[TI] spleen

Cite this page: Mansouri, J. Mycobacteria. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenmycobacteria.html. Accessed July 16th, 2018.
Definition / general
  • Small, weakly gram positive bacteria that are acid fast (due to mycolic acid in cell wall) and slow growers (3 - 4 weeks to develop a visible colony)
  • Mycobacterium avium complex (MAC) consists of M. avium and M. intracellulare, which cause disseminated disease associated with advanced HIV; cause pulmonary disease and cervical lymphadenitis in immunocompetent individuals
  • Disseminated MAC is most common systemic bacterial infection in HIV+ patients
  • Spleen may show presence of pseudo-Gaucher cells (J Clin Pathol 2005;58:1113)
Case reports
  • Clarithromycin or azithromycin plus ethambutol, for life
Microscopic (histologic) images

Images hosted on other servers:

Various images

1: cut surface shows numerous small, white nodules;
2: histiocytes with foamy and granular cytoplasm;
3: abundant acid fast bacteria;
4: EM shows bacilli within large cytoplasmic vacuoles