Infectious / inflammatory disorders
Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 11 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Small, weakly gram positive bacteria that are acid fast (due to mycolic acid in cell wall) and slow growers (3-4 weeks to develop a visible colony)
- Mycobacterium avium complex (MAC) consists of M. avium and M. intracellulare, which cause disseminated disease associated with advanced HIV; cause pulmonary disease and cervical lymphadenitis in immunocompetent individuals
- Disseminated MAC is most common systemic bacterial infection in HIV+ patients
- Spleen may show presence of pseudo-Gaucher cells
(J Clin Pathol 2005;58:1113)
- Clarithromycin or azithromycin plus ethambutol, for life
Figure 1: cut surface shows numerous small, white nodules; 2: histiocytes with foamy and granular cytoplasm; 3: abundant acid-fast bacteria; 4: EM shows bacilli within large cytoplasmic vacuoles|
End of Spleen > Infectious / inflammatory disorders > Mycobacteria
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