Spleen
Infectious / inflammatory disorders
Mycobacteria


Topic Completed: 1 October 2012

Revised: 18 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Mycobacteria[TI] spleen

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Cite this page: Mansouri J. Mycobacteria. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenmycobacteria.html. Accessed August 24th, 2019.
Definition / general
  • Small, weakly gram positive bacteria that are acid fast (due to mycolic acid in cell wall) and slow growers (3 - 4 weeks to develop a visible colony)
  • Mycobacterium avium complex (MAC) consists of M. avium and M. intracellulare, which cause disseminated disease associated with advanced HIV; cause pulmonary disease and cervical lymphadenitis in immunocompetent individuals
  • Disseminated MAC is most common systemic bacterial infection in HIV+ patients
  • Spleen may show presence of pseudo-Gaucher cells (J Clin Pathol 2005;58:1113)
Case reports
Treatment
  • Clarithromycin or azithromycin plus ethambutol, for life
Microscopic (histologic) images

Images hosted on other servers:

Various images

1: cut surface shows numerous small, white nodules;
2: histiocytes with foamy and granular cytoplasm;
3: abundant acid fast bacteria;
4: EM shows bacilli within large cytoplasmic vacuoles

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