Cite this page: Mansouri J. Mycobacteria. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenmycobacteria.html. Accessed May 30th, 2020.
Definition / general
- Small, weakly gram positive bacteria that are acid fast (due to mycolic acid in cell wall) and slow growers (3 - 4 weeks to develop a visible colony)
- Mycobacterium avium complex (MAC) consists of M. avium and M. intracellulare, which cause disseminated disease associated with advanced HIV; cause pulmonary disease and cervical lymphadenitis in immunocompetent individuals
- Disseminated MAC is most common systemic bacterial infection in HIV+ patients
- Spleen may show presence of pseudo-Gaucher cells (J Clin Pathol 2005;58:1113)
- 37 year old white man with advanced HIV and splenomegaly (Arch Pathol Lab Med 2001;125:697)
- Clarithromycin or azithromycin plus ethambutol, for life