Lymph nodes & spleen, nonlymphoma

Topic Completed: 1 October 2012

Minor changes: 22 July 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Peliosis[TI] spleen

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Cite this page: Mansouri J. Peliosis. website. Accessed November 30th, 2020.
Definition / general
  • Also called peliosis lienis
  • Multiple blood filled cystic spaces
  • Usually associated with peliosis hepatis but may be independent
  • Multiple pathogenetic mechanisms possible - may be caused by infection with Bartonella henselae in HIV patients with bacillary angiomatosis
  • May cause splenic rupture and death, particularly in patients with carcinomatosis, chronic leukemia, post liver transplantation, recipients of anabolic androgenic steroids, tuberculosis
Case reports
Microscopic (histologic) description
  • Blood filled sinuses with reduced lining cells, similar to hairy cell leukemia
Microscopic (histologic) images

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Splenic peliosis

Differential diagnosis
Additional references
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