Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Advertisement






General
=========================================================================
Pathophysiology
=========================================================================
Drawings
=========================================================================
Visceral surface
Transverse section highlighting veins
Transverse section highlighting arteries

Gross description
=========================================================================



General - Histology

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 8 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Red pulp: White pulp: Blood flow:
Drawings
=========================================================================
Transverse section


Micro images
=========================================================================
White pulp and red pulp
Periarteriolar lymphoid sheath
Normal white pulp





General - Biopsy

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================



General - Grossing

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================



General - Massive splenomegaly

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================



General - Rupture

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Clinical images
=========================================================================
Splenic laceration due to trauma
Grossly enlarged with hematoma


Gross description
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Subcapsular splenic nodule in splenic pregnancy
Due to pancreatic adenocarcinoma


Additional references
=========================================================================



General - Splenectomy

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Laboratory
=========================================================================
Case reports
=========================================================================
Peripheral blood images
=========================================================================
Howell-Jolly bodies



General - Splenosis

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Clinical images
=========================================================================
Autotransplantation spleen tissues


Micro description
=========================================================================
Differential diagnosis
=========================================================================



Congenital anomalies - Accessory (supernumerary) spleen

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Differential diagnosis
=========================================================================



Congenital anomalies - Asplenia (congenital absence of spleen)

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================



Congenital anomalies - Hepatolienal fusion

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

Case reports
=========================================================================



Congenital anomalies - Hyposplenism

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================



Congenital anomalies - Polysplenia

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================



Congenital anomalies - Splenic-gonadal fusion

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Epidemiology
=========================================================================
Diagnosis
=========================================================================
Case reports
=========================================================================
Treatment
=========================================================================
Gross description
=========================================================================
Gross / micro images
=========================================================================
Figure 1: red-brown firm tumor; 2: tumor is separated from testicle without invasion; 3: tumor has scattered lymphoid follicles with germinal centers; 4: composed of loose reticular tissue with abundant capillaries and venous sinuses
With nonseminomatous germ cell testicular tumor composed of embryonal carcinoma and yolk sac tumor
Micro description
=========================================================================



Congenital anomalies - Splenorenal fusion

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Gross / micro images
=========================================================================
Various images



Congenital anomalies - Wandering spleen

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Clinical images
=========================================================================
Upper smaller spleen
Adhesions to upper border of wandering spleen
Lack of attachment with rest of ptotic spleen





Cysts - Echinococcal cysts

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 10 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================



Cysts - Epithelial cyst

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Multiple splenic cysts with stratified squamous epithelium
Cyst lining is CEA+


Positive stains
=========================================================================
Differential diagnosis
=========================================================================



Cysts - Mesothelial cyst

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 6 December 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Micro description
=========================================================================
Positive stains
=========================================================================
Negative stains
=========================================================================
Differential diagnosis
=========================================================================



Cysts - Pseudocyst

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================



Infectious / inflammatory disorders - Abscess

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================



Infectious / inflammatory disorders - Acute splenitis

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Various images


Differential diagnosis
=========================================================================



Infectious / inflammatory disorders - AIDS

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Micro images
=========================================================================
Normal spleen with abundant white pulp
Mild white-pulp depletion
Moderate white-pulp depletion
Marked white-pulp depletion
Perivascular hyalinization
Large cell lymphoma





Infectious / inflammatory disorders - Foamy macrophages

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 6 December 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Ceroid histiocytes: Gaucher cells: Pseudo-Gaucher cells:
Micro images
=========================================================================
Pseudo-Gaucher cells





Infectious / inflammatory disorders - Follicular hyperplasia

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================



Infectious / inflammatory disorders - Granulomatous inflammation

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 11 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Treatment
=========================================================================



Infectious / inflammatory disorders - Hantavirus

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 11 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================



Infectious / inflammatory disorders - Infectious mononucleosis

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 11 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Clinical images
=========================================================================
Grossly enlarged with haematoma


Micro description
=========================================================================
Positive stains
=========================================================================
Differential diagnosis
=========================================================================



Infectious / inflammatory disorders - Malaria

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 11 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Micro description
=========================================================================
Virtual slides
=========================================================================
Malaria in liver (left) and spleen (right)





Infectious / inflammatory disorders - Mycobacteria

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 11 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Treatment
=========================================================================
Micro images
=========================================================================
Various images
Figure 1: cut surface shows numerous small, white nodules; 2: histiocytes with foamy and granular cytoplasm; 3: abundant acid-fast bacteria; 4: EM shows bacilli within large cytoplasmic vacuoles





Infectious / inflammatory disorders - Parvovirus

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 11 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Micro images
=========================================================================
Erythroid precursors with large pink inclusions





Infectious / inflammatory disorders - Sarcoidosis

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 11 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

Gross images
=========================================================================
Multiple nodular lesions





Infectious / inflammatory disorders - Splendore-Hoeppli phenomenon

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 11 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Micro images
=========================================================================
A/B: abscesses with brightly eosinophilic crystalline structures in starburst pattern; C: gram stain and D: modified acid-fast stain show gram positive, partially acid-fast filamentous organisms, consistent with Nocardia





Infectious / inflammatory disorders - Typhoid fever

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 11 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================



Infectious / inflammatory disorders - Wegener's granulomatosis

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 11 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Micro description
=========================================================================



Other non-neoplastic disorders - Amyloidosis

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 14 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Amyloidosis in spleen and adrenal


Virtual slides
=========================================================================
Amyloidosis


Positive stains
=========================================================================
Differential diagnosis
=========================================================================



Other non-neoplastic disorders - Congestive splenomegaly

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Treatment
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================



Other non-neoplastic disorders - Gaucher's disease

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Treatment
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Various images


Virtual slides
=========================================================================
Gaucher's disease


Positive stains
=========================================================================
Negative stains
=========================================================================
Differential diagnosis
=========================================================================



Other non-neoplastic disorders - Hemolytic anemia

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Treatment
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================



Other non-neoplastic disorders - Hereditary spherocytosis

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Diagrams
=========================================================================
Scatter diagram of CBC


Treatment
=========================================================================
Gross description
=========================================================================
Peripheral blood images
=========================================================================
Small spherocytes


Micro description
=========================================================================
Micro images
=========================================================================
Marked congestion in splenic cords


Virtual slides
=========================================================================
Hereditary spherocytosis





Other non-neoplastic disorders - Hypersplenism

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================



Other non-neoplastic disorders - Immune thrombocytopenic purpura (ITP)

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Prognostic factors
=========================================================================
Treatment
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Figure 1
Figure 2
Figure 3
Figure 4

Fig 1: Well delineated reactive germinal center in splenic white pulp (H&E x100)
Fig 2: Striking lipogranuloma adjacent to splenic white pulp (H&E x100)
Fig 3: Diffuse proliferation of foamy histiocytes (H&E x100)
Fig 4: Extensive extramedullary haematopoiesis with prominent megakaryocyte and erythroblasts present within sinusoids

Electron microscopy description
=========================================================================
Additional references
=========================================================================



Other non-neoplastic disorders - Infarction

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Gross description
=========================================================================
Virtual slides
=========================================================================
Wedge shaped infarct
Infarct





Other non-neoplastic disorders - Lipid histiocytoses

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Micro description
=========================================================================
Positive stains
=========================================================================



Other non-neoplastic disorders - Peliosis

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Micro description
=========================================================================
Differential diagnosis
=========================================================================
Additional references
=========================================================================



Other non-neoplastic disorders - Perisplenitis

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================



Other non-neoplastic disorders - Radiation injury

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================



Other non-neoplastic disorders - Sickle cell disease

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Gross images
=========================================================================
Autosplenectomy


Virtual slides
=========================================================================
Sickle cell disease



Other non-neoplastic disorders - Thrombotic thrombocytopenic purpura

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Micro description
=========================================================================



Other non-neoplastic disorders - Wiskott-Aldrich syndrome

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Micro description
=========================================================================



Hematogenous neoplasms - Lymphoma - general

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Additional references
=========================================================================



Hematogenous neoplasms - Angioimmunoblastic T cell lymphoma

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Angioimmunoblastic T-cell lymphoma
Positive stains
=========================================================================
Molecular / cytogenetics description
=========================================================================



Hematogenous neoplasms - Castleman disease

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Micro description
=========================================================================



Hematogenous neoplasms - Chronic myelogenous leukemia

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================
Positive stains
=========================================================================
Differential diagnosis
=========================================================================



Hematogenous neoplasms - Diffuse large B cell lymphoma

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Treatment
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================
Macronodular: Micronodular: Diffuse red pulp infiltration:
Positive stains
=========================================================================
Negative stains
=========================================================================
Differential diagnosis
=========================================================================



Hematogenous neoplasms - Fibroblastic reticulum cell tumor

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Micro description
=========================================================================
Positive stains
=========================================================================
Negative stains
=========================================================================



Hematogenous neoplasms - Follicular dendritic cell tumor

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

See inflammatory pseudotumor-like variant below

General
=========================================================================
Clinical features
=========================================================================
Case reports
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Tonsil
Tonsil
Liver
Lymph node
Tonsil: CD21
Lymph node: CD35


Positive stains
=========================================================================
Negative stains
=========================================================================
Differential diagnosis
=========================================================================

Inflammatory pseudotumor-like variant
General
=========================================================================



Hematogenous neoplasms - Follicular lymphoma

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Histologic features
Immunohistochemical analysis


Positive stains
=========================================================================
Molecular / cytogenetics description
=========================================================================
Molecular / cytogenetics images
=========================================================================
Fluorescence in situ hybridization analysis


Differential diagnosis
=========================================================================



Hematogenous neoplasms - Hairy cell leukemia

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

See variant type below

General
=========================================================================
Case reports
=========================================================================
Treatment
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================
Spleen: Bone marrow:
Micro images
=========================================================================
Figure 1
TIA1+
Bone marrow smear

Fig 1: Large lymphocytes with abundant cytoplasm, eccentric nuclei, often cytoplasmic projections; 2: TRAP+; 3: hypercellular bone marrow with "fried egg" lymphocytes that are monotonous with abundant cytoplasm

Bone marrow aspirate
CD11c+
CD20+
CD25+
DBA44+


Positive stains
=========================================================================
Negative stains
=========================================================================
Electron microscopy description
=========================================================================
Molecular / cytogenetics description
=========================================================================
Molecular / cytogenetics images
=========================================================================
BRAF V600E Mutation in Hairy-Cell Leukemia (HCL), as Compared with Other Peripheral B-Cell Neoplasms


Differential diagnosis
=========================================================================
Additional references
=========================================================================



Variant type
General
=========================================================================
Case reports
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Various images


Flow cytometry images
=========================================================================
Various images


Positive stains
=========================================================================
Negative stains
=========================================================================
Differential diagnosis
=========================================================================
Additional references
=========================================================================



Hematogenous neoplasms - Hepatosplenic alpha-beta T cell lymphoma

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update March 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Various images


Positive stains
=========================================================================
Molecular / cytogenetics description
=========================================================================
Additional references
=========================================================================



Hematogenous neoplasms - Hepatosplenic gamma-delta T cell lymphoma

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update March 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Primary cutaneous
Liver
Intestine
Other γδ T-cell lymphomas
T-cell lymphoma, TCR silent


Positive stains
=========================================================================
Negative stains
=========================================================================
Molecular / cytogenetics description
=========================================================================
Differential diagnosis
=========================================================================
Additional references
=========================================================================



Hematogenous neoplasms - Histiocytic lymphoma / sarcoma

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update March 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Gross images
=========================================================================
Splenic histiocytic sarcoma


Micro description
=========================================================================
Micro images
=========================================================================
Various images
CD68+, CD163+, lysozyme+
Secondary bone marrow involvement


Positive stains
=========================================================================
Negative stains
=========================================================================
Electron microscopy description
=========================================================================
Differential diagnosis
=========================================================================



Hematogenous neoplasms - Hodgkin lymphoma

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update March 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Gross description
=========================================================================
Gross images
=========================================================================
Scattered gray-white nodules
Few large nodules


Micro description
=========================================================================
Micro images
=========================================================================
Low power view
Higher magnification
Various images


Additional references
=========================================================================



Hematogenous neoplasms - Interdigitating dendritic cell sarcoma

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update March 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Dendritic cells:
Case reports
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================
Positive stains
=========================================================================
Negative stains
=========================================================================
Electron microscopy description
=========================================================================
Differential diagnosis
=========================================================================



Hematogenous neoplasms - Langerhans cell histiocytosis

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update March 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Gross description
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
LCH-site unspecified


Positive stains
=========================================================================
Electron microscopy description
=========================================================================
Molecular / cytogenetics description
=========================================================================
Molecular / cytogenetics images
=========================================================================
Immunofluorescence analysis of BRAF pathway activation in LCH


Additional references
=========================================================================



Hematogenous neoplasms - Lymphoplasmacytic lymphoma

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update March 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Case reports
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Various images
Lymphoplasmacytoid lymphocyte


Positive stains
=========================================================================
Negative stains
=========================================================================
Differential diagnosis
=========================================================================
Additional references
=========================================================================



Hematogenous neoplasms - Mantle cell lymphoma

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update March 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Clinical features
=========================================================================
Case reports
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Expansion of mantle zone
White pulp expanded by proliferation of small lymphocytes
Blastoid variant


Various images


Positive stains
=========================================================================
Negative stains
=========================================================================
Molecular / cytogenetics description
=========================================================================
Molecular / cytogenetics images
=========================================================================
Hypothetical models of two different molecular subtypes of MCL
Major aberrant pathways in MCL susceptible to targeted therapies
Multistep model in progression of MCL
FICTION analysis for t(11;14)(q13;q32)


Differential diagnosis
=========================================================================
Additional references
=========================================================================



Hematogenous neoplasms - Marginal zone B cell lymphoma (Splenic Marginal Zone Lymphoma-SMZL)

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 4 May 2013, last major update April 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================

Case reports
=========================================================================

Gross description
=========================================================================

Gross images
=========================================================================

Markedly enlarged spleen

Micro description
=========================================================================

Micro images
=========================================================================

Prominent white pulp

Various images

Bone marrow biopsy

Cytology description
=========================================================================

Positive stains
=========================================================================

Negative stains
=========================================================================

Molecular / cytogenetics description
=========================================================================

Differential diagnosis
=========================================================================

Additional references
=========================================================================




Hematogenous neoplasms - Mastocytosis

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 4 May 2013, last major update April 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================

WHO Classification
=========================================================================

Diagnosis
=========================================================================

Laboratory
=========================================================================

Case reports
=========================================================================

Gross description
=========================================================================

Micro description
=========================================================================

Micro images
=========================================================================

Spleen in systemic mastocytosis

Mast cell leukemia

Bone marrow biopsy

Positive stains
=========================================================================

Negative stains
=========================================================================

Molecular / cytogenetics description
=========================================================================

Differential diagnosis
=========================================================================




Hematogenous neoplasms - Myelodysplasia

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 8 September 2013, last major update August 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Myelodysplasia[title] spleen

General
=========================================================================

Epidemiology
=========================================================================

Sites
=========================================================================

Pathophysiology
=========================================================================

Etiology
=========================================================================

Clinical features
=========================================================================

Diagnosis
=========================================================================

Prognostic factors
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Micro description
=========================================================================

Micro images
=========================================================================

Erythroid karyorrhexis

Pseudo Pelger-Huët form

Dysmega-karyopoiesis with hypolobated megakaryocytes

Acute myeloid leukemia evolving from MDS

Cytology description
=========================================================================

Positive stains
=========================================================================

Flow cytometry description
=========================================================================

Molecular / cytogenetics description
=========================================================================

Differential diagnosis
=========================================================================




Hematogenous neoplasms - Myelofibrosis

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 30 September 2013, last major update September 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: spleen myelofibrosis

General
=========================================================================

Terminology
=========================================================================

Epidemiology
=========================================================================

Sites
=========================================================================

Pathophysiology
=========================================================================

Etiology
=========================================================================

Clinical features
=========================================================================

Diagnosis
=========================================================================

Laboratory
=========================================================================

Prognostic factors
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Gross description
=========================================================================

Micro description
=========================================================================

Peripheral smear description
=========================================================================

Micro images
=========================================================================

Peripheral blood: megakaryoblasts and platelets

Bone marrow: prominent fibrosis and osteosclerosis

Positive stains
=========================================================================

Negative stains
=========================================================================

Flow cytometry
=========================================================================

Molecular / cytogenetics
=========================================================================

Differential diagnosis
=========================================================================




Hematogenous neoplasms - Peripheral T cell lymphoma (NOS)

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 26 October, last major update October 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Peripheral T cell lymphoma spleen

General
=========================================================================

Terminology
=========================================================================

Epidemiology
=========================================================================

Sites
=========================================================================

Clinical features
=========================================================================

Diagnosis
=========================================================================

Prognostic factors
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Micro description
=========================================================================

Micro images
=========================================================================

Diffuse pattern

Prominent postcapillary venules

Tumor cells with lobated nuclei

Atypical lymphoid infiltrates

CD3+, aberrant CD2+ and CD79+

Positive stains
=========================================================================

Negative stains
=========================================================================

Flow cytometry description
=========================================================================

Molecular / cytogenetics description
=========================================================================

Differential diagnosis
=========================================================================

Additional references
=========================================================================




Hematogenous neoplasms - Plasmacytoma

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 February 2014, last major update December 2013
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.
PubMed Search: Plasmacytoma [title] spleen

General
=========================================================================

Terminology
=========================================================================

Epidemiology
=========================================================================

Sites
=========================================================================

Clinical features
=========================================================================

Diagnosis
=========================================================================

Laboratory
=========================================================================

Prognostic factors
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Gross images
=========================================================================

Well circumscribed nodule in spleen

Micro description
=========================================================================

Positive stains
=========================================================================

Negative stains
=========================================================================

Flow cytometry description
=========================================================================

Differential diagnosis
=========================================================================

Additional references
=========================================================================




Hematogenous neoplasms - Prolymphocytic leukemia

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 12 January 2014, last major update January 2014
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.
PubMed Search: Prolymphocytic leukemia [title] spleen

General
=========================================================================

Terminology
=========================================================================

Epidemiology
=========================================================================

Sites
=========================================================================

Pathophysiology
=========================================================================

Clinical features
=========================================================================

Diagnosis
=========================================================================

Laboratory
=========================================================================

Prognostic factors
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Gross description
=========================================================================

Micro description
=========================================================================

Micro images
=========================================================================

t(11;14)+ cases

t(11;14)- case

Peripheral smear images
=========================================================================

Perpiheral blood and bone marrow

May–Grünwald–Giemsa-stains

Positive stains
=========================================================================

Negative stains
=========================================================================

Flow cytometry description
=========================================================================

Molecular / cytogenetics descriptions
=========================================================================

Differential diagnosis
=========================================================================

Additional references
=========================================================================




Hematogenous neoplasms - Small lymphocytic lymphoma / chronic lymphocytic leukemia (SLL/CLL)

Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 9 Februaury 2014, last major update February 2014
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: spleen[title] Small lymphocytic lymphoma / chronic lymphocytic leukemia

See also Lymphoma chapter: CLL and SLL

General
=========================================================================

Terminology
=========================================================================

Epidemiology
=========================================================================

Sites
=========================================================================

Pathophysiology
=========================================================================

Etiology
=========================================================================

Clinical features
=========================================================================

Diagnosis
=========================================================================

Laboratory
=========================================================================

Prognostic factors
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Gross description
=========================================================================

Gross images
=========================================================================

Miliary pattern of CLL / SLL in spleen

Micro description
=========================================================================

Micro images
=========================================================================

Chronic lymphocytic leukemia-bone marrow aspirate

Peripheral smear images
=========================================================================

Heterogeneity

Characteristic "cobblestone" pattern

Lymphocytes as well as "smudge" cells

Positive stains
=========================================================================

Negative stains
=========================================================================

Flow cytometry description
=========================================================================

Molecular / cytogenetics descriptions
=========================================================================

Differential diagnosis
=========================================================================

Additional references
=========================================================================




Vascular tumors - Angiosarcoma

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 26 August 2013, last major update August 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Angiosarcoma of spleen

General
=========================================================================

Terminology
=========================================================================

Epidemiology
=========================================================================

Pathophysiology
=========================================================================

Clinical features
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Gross description
=========================================================================

Gross images
=========================================================================

Extensive necrosis

Hemorrhagic and nodular lesions

Hemorrhagic lesion in the spleen

Micro description
=========================================================================

Micro images
=========================================================================

Sinusoidal and cavernous growth patterns

Anastomosing vascular channels

Closely packed vascular channels lined by atypical endothelial cells

Replacement of red pulp with sparing of white pulp

A: slitlike spaces; B: anastomosing vascular channels have honeycomb appearance


A: capillary vascular channels; B: fascicles of spindle cells resembling fibrosarcoma

Papillary structures with hyaline cores

Epithelioid tumor

A: hemophagocytosis and phagocytosis of hyaline globules; B: extramedullary hematopoiesis


Proliferating nodules in spleen

Cellular pleomorphism and mitoses in nodules

Diffuse staining with CD31

Positive for vascular endothelial growth factor receptor 3

Kaposi-like variant

Positive stains
=========================================================================

Negative stains
=========================================================================

Electron microscopy description
=========================================================================

Differential diagnosis
=========================================================================




Vascular tumors - Bacillary angiomatosis

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 22 September 2013, last major update September 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Bacillary angiomatosis [title]

General
=========================================================================

Terminology
=========================================================================

Sites
=========================================================================

Pathophysiology
=========================================================================

Clinical features
=========================================================================

Diagnosis
=========================================================================

Laboratory
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Micro description
=========================================================================

Micro images
=========================================================================

Soft tissue: capillaries with pink granular material in interstitium

Warthin Starry stain demonstrating bacilli

Positive stains
=========================================================================

Electron microscopy description
=========================================================================

Electron microscopy images
=========================================================================

Skin: bacilli with trilaminar cell walls

Differential diagnosis
=========================================================================




Vascular tumors - Hamartoma

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 21 November 2014, last major update October 2013
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.
PubMed Search: Spleen hamartoma

General
=========================================================================

Terminology
=========================================================================

Epidemiology
=========================================================================

Clinical features
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Clinical images
=========================================================================

Hypodense mass of the spleen

Homogenous and hypoechoic mass

Isointense mass (arrows)

Gross description
=========================================================================

Gross images
=========================================================================

Tumor-like mass

Nodule of increased stiffness

Resected spleen

Varying sizes of vascular spaces

Micro description
=========================================================================

Micro images
=========================================================================

Red pulp splenic sinusoidal structure

Splenic red pulp element

Entrapped clusters of adipocytes

Nonencapsulated nodule

Positive for reticulin

Positive stains
=========================================================================

Electron microscopy images
=========================================================================

Tall lining cells

Molecular / cytogenetics description
=========================================================================

Differential diagnosis
=========================================================================

Additional references
=========================================================================




Vascular tumors - Hemangioendothelioma

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 31 October 2013, last major update October 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Hemangioendothelioma spleen

General
=========================================================================

Epidemiology
=========================================================================

Clinical features
=========================================================================

Diagnosis
=========================================================================

Radiology
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Clinical images
=========================================================================

Large protruding cystic mass

Hypodense lesions

Gross description
=========================================================================

Gross images
=========================================================================

Multicystic lesion

Micro description
=========================================================================

Micro images
=========================================================================

Uniform population of spindle cells

Composite hemangioendothelioma

Abundant pale eosinophilic cytoplasm

Vascular channels lined by plump epithelial cells

Positive stains
=========================================================================

Differential diagnosis
=========================================================================




Vascular tumors - Hemangioma

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 17 November 2013, last major update November 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Hemangioma spleen

General
=========================================================================

Epidemiology
=========================================================================

Clinical features
=========================================================================

Diagnosis
=========================================================================

Radiology
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Clinical images
=========================================================================

Giant splenic hemangioma

Cavernous splenic hemangioma

Splenomegaly and hemangiomas

Gross description
=========================================================================

Gross images
=========================================================================

Cavernous hemangioma

Micro description
=========================================================================

Micro images
=========================================================================

Vascular channels lined by plump endothelial cells

Multiple blood filled spaces

Vascular spaces of irregular size

Positive stains
=========================================================================

Negative stains
=========================================================================

Differential diagnosis
=========================================================================




Vascular tumors - Hemangiopericytoma

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 16 December 2013, last major update December 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Hemangiopericytoma [title] spleen

General
=========================================================================

Epidemiology
=========================================================================

Clinical features
=========================================================================

Diagnosis
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Clinical images
=========================================================================

Active bleeding in splenic cystic lesion

Gross description
=========================================================================

Gross images
=========================================================================

Multiple lobulated, solid,
well circumscribed nodules

Micro description
=========================================================================

Micro images
=========================================================================

Dilated sinuous vascular channels
(H&E and reticulin)

Positive stains
=========================================================================

Negative stains
=========================================================================

Molecular / cytogenetics description
=========================================================================




Vascular tumors - Littoral cell angioma

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 16 December 2013, last major update December 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: littoral cell angioma spleen

General
=========================================================================

Epidemiology
=========================================================================

Clinical features
=========================================================================

Radiology
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Gross description
=========================================================================

Gross images
=========================================================================

Multiple nodules

Micro description
=========================================================================

Micro images
=========================================================================

Neoplastic sinuses

Tumor and normal spleen

Anastomosing vascular spaces

Papillary projections


Large blood-filled
cystic spaces

Intracytoplasmic eosinophilic globules

CD31+, CD68+

Positive stains
=========================================================================

Negative stains
=========================================================================

Differential diagnosis
=========================================================================

Additional references
=========================================================================




Vascular tumors - Lymphangioma

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 16 December 2013, last major update December 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Lymphangioma [title] spleen

General
=========================================================================

Epidemiology
=========================================================================

Pathophysiology
=========================================================================

Clinical features
=========================================================================

Radiology
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Gross description
=========================================================================

Gross images
=========================================================================

Multilocular cystic
mass

Multiple, thin-walled cystic spaces

4.5 cm × 3.5 cm bulging cystic mass

4.5 cm × 4.5 cm retroperitoneal mass

Micro description
=========================================================================

Micro images
=========================================================================

Cystic spaces lined by attenuated endothelium

H&E staining

H&E and D2-40

Retroperitoneal lymphangioma

Positive stains
=========================================================================

Differential diagnosis
=========================================================================




Vascular tumors - Sclerosing angiomatoid nodular transformation

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 12 January 2014, last major update January 2014
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.
PubMed Search: sclerosing angiomatoid nodular transformation of the spleen

General
=========================================================================

Epidemiology
=========================================================================

Pathophysiology
=========================================================================

Clinical features
=========================================================================

Radiology
=========================================================================

Prognostic factors
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Clinical images
=========================================================================

Well-circumscribed highly vascularised lesion

Expansible low density mass

5-cm tumor in hilus

Hypointensity of tumor

Splenic lesion at medial aspect

Lesion in lower spleen

Hypoenhancing mass

Solid tumor

Laparoscopic view

Gross description
=========================================================================

Gross images
=========================================================================

Well-defined nonencapsulated lesion

Well-demarcated, unencapsulated, dark brown mass

0.3–0.5 cm red-brown multinodular lesions

Splenic resection

Micro description
=========================================================================

Micro images
=========================================================================

Angiomatoid nodules

Slit-like, round irregular-shaped vascular spaces

Concentric rims of collagen fibrils


CD31 highlights the abundant vascular structures

CD34 highlights the capillaries

CD8 highlights occasional sinusoid-like spaces

CD68 highlights scattered single cells

Positive stains
=========================================================================

Electron microscopy descriptions
=========================================================================

Differential diagnosis
=========================================================================




Other tumors - Ectopic adrenal myelolipoma

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 23 January 2014, last major update Janaury 2014
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.
PubMed Search: Ectopic adrenal myelolipoma

General
=========================================================================

Epidemiology
=========================================================================

Pathophysiology
=========================================================================

Clinical features
=========================================================================

Clinical images
=========================================================================

Large well circumscribed soft tissue masses

Intrasplenic myelolipoma

Case reports
=========================================================================

Treatment
=========================================================================

Gross description
=========================================================================

Gross images
=========================================================================

Horizontal section of spleen

Resected extra-adrenal myelolipoma

Micro description
=========================================================================

Micro images
=========================================================================

Adipocytes and bone marrow elements




Other tumors - Inflammatory myofibroblastic tumor

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 23 January 2014, last major update January 2014
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.
PubMed Search: Inflammatory myofibroblastic tumor [title] spleen

General
=========================================================================

Epidemiology
=========================================================================

Pathophysiology
=========================================================================

Clinical features
=========================================================================

Radiology
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Clinical images
=========================================================================

Diffuse and inhomogeneous enhancement

Hepatic and splenic lesions

Splenic mass

Hypodense mass



Splenic lesion

Hypoechoic lesion

PET scan

Gross description
=========================================================================

Gross images
=========================================================================

Splenectomy specimen

Multinodular borders

Well-circumscribed, centrally necrotic, tan, fleshy mass

Micro description
=========================================================================

Micro images
=========================================================================

Various images


Smooth muscle actin

CD35

EBV by ISH

Positive stains
=========================================================================

Negative stains
=========================================================================

Differential diagnosis
=========================================================================

Additional references
=========================================================================




Other tumors - Malignant fibrous histiocytoma

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 9 February 2014, last major update February 2014
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.
PubMed Search: Malignant fibrous histiocytoma [title] spleen

General
=========================================================================

Epidemiology
=========================================================================

Clinical features
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Clinical images
=========================================================================

Hepatic cyst with splenic MFH

Gross description
=========================================================================

Gross images
=========================================================================

11 cm mass with necrosis

Micro description
=========================================================================

Micro images
=========================================================================

Various images

Vimentin and CD68

CD68

Positive stains
=========================================================================




Other tumors - Metastases

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 9 February 2014, last major update February 2014
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.
PubMed Search: Metastases [title] spleen

General
=========================================================================

Epidemiology
=========================================================================

Pathophysiology
=========================================================================

Clinical features
=========================================================================

Diagnosis
=========================================================================

Radiology
=========================================================================

Case reports
=========================================================================

Treatment
=========================================================================

Clinical images
=========================================================================

F-FDG PET images of splenic metastasis

CT images of splenic metastasis

Gross description
=========================================================================

Gross images
=========================================================================

Splenic metastasis

Micro description
=========================================================================

Micro images
=========================================================================

Parotid gland: carcinoma ex pleomorphic adenoma




Other tumors - Mucinous cystadenocarcinoma

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 26 February 2014, last major update February 2014
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.
PubMed Search: Mucinous cystadenocarcinoma [title] spleen

General
=========================================================================

Clinical features
=========================================================================

Radiology
=========================================================================

Case reports
=========================================================================

Gross description
=========================================================================

Gross images
=========================================================================

Mucinous cysts

Micro description
=========================================================================

Differential diagnosis
=========================================================================

Additional references
=========================================================================

End of Spleen > Superpage



Advertisement




This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).