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Stains

OSCAR Cytokeratin

Authors: Kara Hamilton, M.S. and Nat Pernick, M.D., PathologyOutlines.com, Inc.

Revised: 2 July 2009, last major update July 2009

Terminology

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● Also called CK Oscar or Oscar Keratin

Uses

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● Broad spectrum keratin; distinguishes carcinomas from non-epithelial malignancies

Interpretation

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● Cytoplasmic staining

Positive stains - normal

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● Epithelium of bile ducts, bladder (urothelium), breast ducts, bronchi, colorectum, duodenum, endometrium, ileum, ovary, pancreas, prostate, stomach, thyroid

● Also hepatocytes, pituitary acini, pneumocytes

Positive stains - disease

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● Most carcinomas

● Also alveolar rhabdomyosarcoma (50%, Mod Pathol 2008;21:795)

Negative stains

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● Brain, endothelium, lymphocyte, muscle, nerves

● GIST, lymphoma, melanoma, sarcoma, schwannoma

Micro images

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Site unknown                                      Alveolar rhabdomyosarcoma        

(figure b)

MPNST                                                  Anaplastic lymphoma (negative)

Additional references

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● Sources for OSCAR keratin (advertisements): Covance

End of Stains chapter > OSCAR Cytokeratin

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