Pathology Outlines

Stains
11A1

Author: Nat Pernick, M.D (see Authors page)

Revised: 2 September 2015, last major update July 2015

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: 11A1[title]

Table of Contents

Definition / general | Clinical features | Uses by pathologists

Cite this page: 11A1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stains11A1.html. Accessed July 12th, 2017.

Definition / general

Procollagen 11A1 is overexpressed in desmoplastic stroma (Int J Oncol 2012;40:1447)
Note: 11A1 also refers to a mitochondrial cytochrome P450 enzyme (Lipids 2008;43:1127)
Note: Slc11a1 refers to solute carrier family 11, a different entity (WikiGenes)

Clinical features

Essential for normal skeletal development; mutations cause Marshall and Stickler syndromes, both characterized by craniofacial abnormalities, nearsightedness and hearing deficiencies (Matrix Biol 2008;27:330)

Uses by pathologists

May be marker of desmoplasia