14-3-3sigma protein (Stratifin)
Reviewer: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 6 April 2011, last major update April 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
● Note: searching 14-3-3 sigma (with the space) reduces PubMed search results
● Member of highly conserved family of acidic proteins
● Transcriptionally activated by p53 after DNA damage; facilitates DNA repair during G2 arrest
● Inactivated in some malignancies, due to promoter hypermethylation (Mod Pathol 2005;18:340, Am J Clin Pathol 2010;133:232 )
● Non-routine myoepithelial marker in breast (Am J Surg Pathol 2005;29:347)
Expression in normal and malignant tissue
Positive staining - normal
● Urothelium, prostate and breast periductal and periglandular cells, uterus (strong in squamous epithelium, weak in endometrial and endocervical glands)
Positive staining - tumors
● Bladder urothelial carcinoma (98%), cervical squamous cell carcinoma (67%), endometrial adenocarcinoma (57%), prostatic adenocarcinoma (55%), ovarian carcinoma (33%), testicular tumors (27%), breast carcinoma (23%), renal carcinoma (12%)
● Germinal cells of testis and ovary, kidney (sporadic expression in tubules)
End of Stains > 14-3-3sigma protein
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