14-3-3sigma protein (stratifin)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 November 2015, last major update July 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: (14-3-3sigma [title]) OR 14-3-3 sigma[title]
Cite this page: 14-3-3sigma protein (stratifin). website. Accessed February 19th, 2018.
Definition / general
Clinical features
Diagrams / tables

Function in DNA damage response

Uses by pathologists
  • None at this time
Microscopic (histologic) images

Images hosted on other servers:

Breast: normal to invasive carcinoma

Cervix: normal

Cervix: LSIL

Cervix: HSIL

Cervix: invasive squamous cell carcinoma

Lung: non-small cell cancer

Lung: adenocarcinoma

Oral cavity: normal to carcinoma

Oral cancer (fig 1B)

Stomach: normal and carcinoma

Images hosted on
Missing Image

GU and Gyn: normal to malignant

Positive staining - normal
  • Breast and prostate periductal and periglandular cells, urothelium, uterus (strong in squamous epithelium, weak in endometrial and endocervical glands)
  • Myoepithelial marker in breast (Am J Surg Pathol 2005;29:347)
Positive staining - disease
  • Bladder urothelial carcinoma (98%), breast carcinoma (23%), cervical squamous cell carcinoma (67%), endometrial adenocarcinoma (57%), ovarian carcinoma (33%), prostatic adenocarcinoma (55%), renal carcinoma (12%), testicular tumors (27%)
Negative stains
  • Kidney (sporadic expression in tubules), germinal cells of ovary and testis