14-3-3sigma protein (stratifin)

Topic Completed: 1 July 2013

Minor changes: 4 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: (14-3-3sigma [title]) OR 14-3-3 sigma[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. 14-3-3sigma protein (stratifin). website. Accessed June 1st, 2020.
Definition / general
Clinical features
Diagrams / tables

Function in DNA damage response

Uses by pathologists
  • None at this time
Microscopic (histologic) images

Images hosted on other servers:

Breast: normal to invasive carcinoma

Lung: non-small cell cancer

Lung: adenocarcinoma

Oral cavity: normal to carcinoma

Oral cancer (fig 1B)

Stomach: normal and carcinoma

Positive staining - normal
  • Breast and prostate periductal and periglandular cells, urothelium, uterus (strong in squamous epithelium, weak in endometrial and endocervical glands)
  • Myoepithelial marker in breast (Am J Surg Pathol 2005;29:347)
Positive staining - disease
  • Bladder urothelial carcinoma (98%), breast carcinoma (23%), cervical squamous cell carcinoma (67%), endometrial adenocarcinoma (57%), ovarian carcinoma (33%), prostatic adenocarcinoma (55%), renal carcinoma (12%), testicular tumors (27%)
Negative stains
  • Kidney (sporadic expression in tubules), germinal cells of ovary and testis
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