14-3-3sigma protein (stratifin)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 9 September 2015, last major update July 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: (14-3-3sigma [title]) OR 14-3-3 sigma[title]
Clinical Features

Function in DNA damage response

Uses by Pathologists
  • None at this time
Micro Images

Breast: normal to invasive carcinoma

Cervix: normal

Cervix: LSIL

Cervix: HSIL

Cervix: invasive squamous cell carcinoma

Missing Image

GU and Gyn: normal to malignant

Lung: non-small cell cancer

Lung: adenocarcinoma

Oral cavity: normal to carcinoma

Oral cancer (fig 1B)

Stomach: normal and carcinoma

Positive Staining - Normal
  • Breast and prostate periductal and periglandular cells, urothelium, uterus (strong in squamous epithelium, weak in endometrial and endocervical glands)
  • Myoepithelial marker in breast (Am J Surg Pathol 2005;29:347)
Positive Staining - Disease
  • Bladder urothelial carcinoma (98%), breast carcinoma (23%), cervical squamous cell carcinoma (67%), endometrial adenocarcinoma (57%), ovarian carcinoma (33%), prostatic adenocarcinoma (55%), renal carcinoma (12%), testicular tumors (27%)
Negative Stains
  • Kidney (sporadic expression in tubules), germinal cells of ovary and testis