Stains - 14-3-3sigma protein

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Stains

14-3-3sigma protein (Stratifin)

Reviewer: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 6 April 2011, last major update April 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Terminology
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● Note: searching 14-3-3 sigma (with the space) reduces PubMed search results

Physiology
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● Member of highly conserved family of acidic proteins
● Transcriptionally activated by p53 after DNA damage; facilitates DNA repair during G2 arrest
● Inactivated in some malignancies, due to promoter hypermethylation (Mod Pathol 2005;18:340, Am J Clin Pathol 2010;133:232 )

Uses
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● Non-routine myoepithelial marker in breast (Am J Surg Pathol 2005;29:347)

Micro images
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Expression in normal and malignant tissue

Positive staining - normal
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● Urothelium, prostate and breast periductal and periglandular cells, uterus (strong in squamous epithelium, weak in endometrial and endocervical glands)

Positive staining - tumors
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● Bladder urothelial carcinoma (98%), cervical squamous cell carcinoma (67%), endometrial adenocarcinoma (57%), prostatic adenocarcinoma (55%), ovarian carcinoma (33%), testicular tumors (27%), breast carcinoma (23%), renal carcinoma (12%)

Negative staining
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● Germinal cells of testis and ovary, kidney (sporadic expression in tubules)

End of Stains > 14-3-3sigma protein

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