Pathology Outlines - 15-PGDH

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Stains
15-PGDH

Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 November 2015, last major update July 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: 15-PGDH

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Table of Contents

Definition / general | Diagrams / tables | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease

Cite this page: 15-PGDH. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stains15pgdh.html. Accessed July 12th, 2017.

Definition / general

NAD(+) dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), also called HPGD
Enzyme that inactives prostaglandin (PG) E2 by oxidizing its hydroxyl group to a ketone, leading to loss of biological activity
A metabolic antagonist of cyclooxygenase-2 (COX2), a rate-limiting enzyme in biosynthesis of PGE2 (Biochem Pharmacol 2011;82:1352)
Regulated by NSAIDs (Prostaglandins Other Lipid Mediat 2011;96:37, Arch Biochem Biophys 2009;487:139)
Acts as a tumor suppressor in bladder (Am J Pathol 2010;176:1462), breast (Cancer Res 2006;66:7818), colorectal (J Korean Soc Coloproctol 2012;28:253), lung (Carcinogenesis 2005;26:65, Prostaglandins Other Lipid Mediat 2007;83:203) and stomach cancer (World J Gastroenterol 2012;18:1028); also in pituitary adenoma (Oncol Rep 2012;28:714)
H. pylori may promote gastric carcinogenesis by suppressing 15-PGDH (Cancer Prev Res (Phila) 2013;6:349)
In breast cancer, 15-PDGH also associated with aggressive behavior (J Pathol 2012;226:674)

Diagrams / tables

PGE2 synthesis, degradation and regulation

Uses by pathologists

Apocrine marker for benign and most malignant apocrine breast lesions

Microscopic (histologic) images

Images hosted on other servers:

Bladder: normal (left) and carcinoma

Breast: benign apocrine and malignant lesions

Colon: normal

Colon: normal and cancer

Liver: normal

Lung: normal and carcinoma

Prostate: normal

Stomach: normal and cancer

Synovium: healthy and inflamed

Synovium: rheumatoid arthritis

Uterus: endometrial adenocarcinoma

Positive staining - normal

Apocrine sweat glands; various epithelium

Positive staining - disease

Apocrine benign and malignant breast lesions (Mol Oncol 2009;3:220, Mol Cell Proteomics 2006;5:462)

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