Stains - 15-PGDH

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Stains

15-PGDH

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 27 December 2011, last major update December 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
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● 15-hydroxyprostaglandin dehydrogenase (15-PGDH), also called HPGD, oxidizes hydroxyl group of prostaglandins to a ketone, leading to loss of biological activity; inhibited by aspirin and NSAIDs
● Also a tumor suppressor (Carcinogenesis 2005;26:65)

Uses by pathologists
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● Apocrine marker for benign and most malignant apocrine breast lesions

Micro images
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Breast: apocrine cysts and benign lesions

Breast: various benign and malignant lesions

Lung: normal and carcinoma

Positive staining - normal
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● Apocrine sweat glands

Positive staining - disease
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● Apocrine benign and malignant breast lesions (Mol Oncol 2009;3:220)

End of Stains > 15-PGDH

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