Topic Completed: 1 July 2013

Revised: 4 March 2019

Copyright: 2003-2015,, Inc.

PubMed Search: 45M1

Nat Pernick, M.D.
Page views in 2019: 23
Cite this page: Pernick N. 45M1. website. Accessed February 27th, 2020.
Definition / general
  • Antibody against MUC5AC, a gastric mucin, with epitope located in the C-terminal cysteine-rich part (FEBS J 2008;275:481)
Uses by pathologists
  • To detect gastric mucins
Case reports
  • 58 year old man with recurrence of gastric cancer with mucin phenotype (Surg Today 2007;37:325)
  • 78 year old man with 45M1+ ampullary signet-ring cell carcinoma and ampullary adenocarcinoma (JOP 2011;12:162)
Microscopic (histologic) images

Images hosted on other servers:

Ampulla of Vater: coexisting signet-ring cell carcinoma and adenocarcinoma (45M1+, fig 4)


Pancreas: mucous gland hyperplasia (45M1+)

Stomach (distal): < 1 mm lesions of well-differentiated adenocarcinoma (45M1+)

Positive staining - normal
  • Gastric epithelium
Positive staining - disease
Negative staining
  • Mature small intestinal goblet cells
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