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Stains

45M1

Reviewer: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 20 April 2011, last major update April 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
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● Antibody against MUC5AC, a gastric mucin, with epitope located in the C-terminal cysteine-rich part (FEBS J 2008;275:481)

Uses
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● To detect gastric mucins

Micro images
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Coexisting signet-ring cell carcinoma and adenocarcinoma of ampulla of Vater are both 45M1 positive


Super-minute lesions (< 1 mm) of well-differentiated adenocarcinoma in distal stomach are 45M1 positive


Mucous gland hyperplasia of pancreas is 45M1 positive

Positive staining - normal
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● Gastric epithelium

Positive staining - disease
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● Barrett’s esophagus and intestinal metaplasia of gastroesophageal junction (Am J Surg Pathol 2001;25:87)
● Mucous gland hyperplasia of pancreas (J Carcinog 2005;4:9)

Negative staining
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● Mature small intestinal goblet cells

End of Stains > 45M1

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