Pathology Outlines

Stains
45M1

Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 November 2015, last major update July 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: 45M1

Table of Contents

Cite this page: 45M1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stains45M1.html. Accessed July 12th, 2017.

Definition / general

Antibody against MUC5AC, a gastric mucin, with epitope located in the C-terminal cysteine-rich part (FEBS J 2008;275:481)

Uses by pathologists

To detect gastric mucins

Case reports

58 year old man with recurrence of gastric cancer with mucin phenotype (Surg Today 2007;37:325)
78 year old man with 45M1+ ampullary signet-ring cell carcinoma and ampullary adenocarcinoma (JOP 2011;12:162)

Microscopic (histologic) images

Images hosted on other servers:

Ampulla of Vater: coexisting signet-ring cell carcinoma and adenocarcinoma (45M1+, fig 4)

Bowel

Pancreas: mucous gland hyperplasia (45M1+)

Stomach (distal): < 1 mm lesions of well-differentiated adenocarcinoma (45M1+)

Positive staining - normal

Gastric epithelium

Positive staining - disease

Barrett’s esophagus and intestinal metaplasia of gastroesophageal junction (Am J Surg Pathol 2001;25:87)
Mucous gland hyperplasia of pancreas (J Carcinog 2005;4:9)
Distal stomach super-minute well-differentiated adenocarcinoma lesions (J Carcinog 2005;4:14)

Negative staining

Mature small intestinal goblet cells