Reviewer: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 20 April 2011, last major update April 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
● Antibody against MUC5AC, a gastric mucin, with epitope located in the C-terminal cysteine-rich part (FEBS J 2008;275:481)
● To detect gastric mucins
Coexisting signet-ring cell carcinoma and adenocarcinoma of ampulla of Vater are both 45M1 positive
Super-minute lesions (< 1 mm) of well-differentiated adenocarcinoma in distal stomach are 45M1 positive
Mucous gland hyperplasia of pancreas is 45M1 positive
Positive staining - normal
● Gastric epithelium
Positive staining - disease
● Barrett’s esophagus and intestinal metaplasia of gastroesophageal junction (Am J Surg Pathol 2001;25:87)
● Mucous gland hyperplasia of pancreas (J Carcinog 2005;4:9)
● Mature small intestinal goblet cells
End of Stains > 45M1
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