Stains - AF-4

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Stains

AF-4

Reviewer: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 29 April 2011, last major update April 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
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● Gene at 4q21
● Part of translocations with MLL via t(4;11)(q21;q23 ), common in infantile acute lymphoblastic leukemia; rarely occurs in AML

Pathophysiology
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● AF4 complex provides several activities that could activate RNA polymerase II; in contrast, AF4–MLL fusion protein complex appears to activate transcription in an autonomous manner, which may lead to epigenetic changes in transcribed chromatin regions (Leukemia 2011;25:135)

End of Stains > AF-4

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