Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 14 September 2013, last major update September 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
PubMed Search: AF4[title]
- Member of protein family implicated in childhood lymphoblastic leukemia, FRAXE (Fragile X E site) mental retardation and ataxia
Also called AF4/FMR2 family, member 1 (GeneCards)
- Transcriptional activator at 4q21 involved in transcriptional elongation
- Has central role in RNA Pol II mediated transcription and phosphorylation-dependent regulatory mechanisms (Biochem J 2011;438:649)
- MLL-AF4 translocation of t(4;11)(q21;q23 ) is common in infantile acute lymphoblastic leukemia (Genes Chromosomes Cancer 2013;52:954); rarely acute megakaryoblastic leukemia (Eur J Haematol 2009;83:149)
- AF4 complex provides several activities that could activate RNA polymerase II; in contrast, AF4-MLL protein disturbs the fine-tuned activation cycle of promoter-arrested RNA Pol II, and causes altered histone methylation signatures (Leukemia 2011;25:135)
CNS: left-cerebellum; right-cortex
End of Stains > AF4
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