Topic Completed: 1 September 2013

Revised: 7 January 2019, last major update September 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: AF4[title]

Nat Pernick, M.D.
Page views in 2019: 25
Page views in 2020 to date: 7
Cite this page: Pernick N. AF4. website. Accessed May 31st, 2020.
Definition / general
  • Member of protein family implicated in childhood lymphoblastic leukemia, FRAXE (Fragile X E site) intellectual disability and ataxia, also called AF4/FMR2 family, member 1 (GeneCards)
  • Transcriptional activator at 4q21 involved in transcriptional elongation
  • Has central role in RNA Pol II mediated transcription and phosphorylation-dependent regulatory mechanisms (Biochem J 2011;438:649)
  • MLL-AF4 translocation of t(4;11)(q21;q23 ) is common in infantile acute lymphoblastic leukemia (Genes Chromosomes Cancer 2013;52:954); rarely acute megakaryoblastic leukemia (Eur J Haematol 2009;83:149)
  • AF4 complex provides several activities that could activate RNA polymerase II; in contrast, AF4-MLL protein disturbs the fine-tuned activation cycle of promoter-arrested RNA Pol II, and causes altered histone methylation signatures (Leukemia 2011;25:135)
Microscopic (histologic) images

Images hosted on other servers:

CNS: left-cerebellum; right-cortex

Breast carcinoma (second image)

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