D2-40 (Podoplanin)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 December 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Podoplanin[title] or d2-40[title]
Cite this page: D2-40 (Podoplanin). website. Accessed June 20th, 2018.
Definition / general
  • 38 kDa membrane mucoprotein originally detected on surface of rat podocytes
  • Antibody D2-40 reacts to an O-linked, 40 kDa sialoglycoprotein found on lymphatic endothelium, fetal testis and on the surface of testicular germ cell tumors (also other cells as indicated below)
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Lymphatics in normal lymph node (fig A) and normal breast

Various Images

Colon-ulcerative colitis

Colon-various polyps

Colon-invasive carcinoma

Invasive breast carcinoma - lymphatics are D2-40 positive

Invasive breast carcinoma - lymphatics are D2-40 positive

Epithelioid angiosarcoma

Melanoma lymphatics

Melanoma tumor emboli

Follicular dendritic cell tumors

In laryngeal squamous cell carcinoma

Images hosted on

Mesothelium (pleura)

Angiomyolipoma - lymphatics are prominent

Angiosarcoma and lymphangioma

Invasive breast carcinoma - lymphatics are D2-40 positive

Kaposi sarcoma

Kaposiform hemangi

Mesothelioma (fig b)

Seminoma of testis

Embryonal carcinoma of testis

Lymphatic invasion in clear cell renal cell carcinoma

Lymphatic invasion in gastric carcinoma

Lymphatic invasion: within venous media

In papillary thyroid carcinoma angiosarcoma

Positive staining - normal
Positive staining - disease
Negative staining
Electron microscopy images

Dermal lymphatics

Additional references