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Stains
D2-40 (Podoplanin)

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 2 October 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Podoplanin[title] or d2-40[title]

General
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Uses by pathologists
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Micro images
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Lymphatics in normal lymph node (fig A) and normal breast

Mesothelium (pleura)

Lymphatics versus endothelium (site unspecified)

Angiomyolipoma - lymphatics are prominent

Angiosarcoma and lymphangioma


Colon-ulcerative colitis

Colon-various polyps

Colon-invasive carcinoma

Invasive breast carcinoma - lymphatics are D2-40 positive

Invasive breast carcinoma - lymphatics are D2-40 positive

Kaposi sarcoma

Epithelioid angiosarcoma

Kaposiform hemangi
oendothelioma


Melanoma lymphatics

Melanoma tumor emboli

Mesothelioma (fig b)

Follicular dendritic cell tumors


Seminoma of testis

Embryonal carcinoma of testis


Lymphatic invasion in clear cell renal cell carcinoma


Lymphatic invasion in gastric carcinoma

Lymphatic invasion: within venous media

In papillary thyroid carcinoma angiosarcoma

In laryngeal squamous cell carcinoma

Positive staining - normal
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Positive staining - disease
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Negative staining
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Electron microscopy images
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Dermal lymphatics

Additional references
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End of Stains > D2-40 (Podoplanin)


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