D2-40 (Podoplanin)

Author: Nat Pernick, M.D.

Revised: 16 October 2018, last major update June 2005

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Podoplanin[title] or d2-40[title] Review[ptyp]
Cite this page: Pernick, N. D2-40 (Podoplanin). website. Accessed November 12th, 2018.
Definition / general
  • 38 kDa membrane mucoprotein originally detected on surface of rat podocytes
  • Antibody D2-40 reacts to an O-linked, 40 kDa sialoglycoprotein found on lymphatic endothelium, fetal testis and on the surface of testicular germ cell tumors (also other cells as indicated below)
Uses by pathologists
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Debra Zynger, M.D.

Seminoma with IHC



Images hosted on other servers:

Lymphatics in normal lymph node (fig A) and normal breast

Various Images

Colon - ulcerative colitis

Colon - various polyps

Colon - invasive carcinoma

Invasive breast carcinoma - lymphatics are D2-40 positive

Invasive breast carcinoma - lymphatics are D2-40 positive

Epithelioid angiosarcoma

Melanoma lymphatics

Melanoma tumor emboli

Follicular dendritic cell tumors

In laryngeal squamous cell carcinoma

Angiosarcoma and lymphangioma

Kaposi sarcoma

Positive staining - normal
Positive staining - disease
Negative staining
Electron microscopy images

Images hosted on other servers:

Dermal lymphatics

Additional references