Pathology Outlines

Stains
DOG1

Author: Nat Pernick, M.D. (see Authors page)

Revised: 8 December 2015, last major update November 2011

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: DOG1 [title]

Table of Contents

Cite this page: DOG1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsDOG1.html. Accessed July 12th, 2017.

Definition / general

Discovered On GIST 1
Chloride channel protein

Interpretation

Membranous and cytoplasmic staining

Uses by pathologists

Sensitive and specific marker for GIST (Gut Liver 2011;5:171)
May be more sensitive and specific for GIST than CD117 / KIT in cell blocks (Cancer Cytopathol 2011;119:202, Am J Clin Pathol 2011;135:448)
Sensitive for CD117 negative GIST tumor (non-GI tumors are usually DOG1+, Am J Surg Pathol 2011;35:1287, Mod Pathol 2011;24:866)
Negative staining suggests tumor is not GIST (Cancer Control 2011;18:152)
Distinguish gastric plexiform fibromyxoma (alpha smooth muscle actin+, KIT-, DOG1-, CD34-, no KIT / PDGFRA mutations) from GIST (opposite, Am J Surg Pathol 2009;33:1624)
Marker for interstitial cells of Cajal in GI tract

Microscopic (histologic) images

Images hosted on Other servers:

GIST

GIST: p16, DOG1 and PDGFRA

GIST and other tumors

Positive staining - normal

Gastric epithelium, interstitial cells of Cajal, pancreatic centroacinar cells (Hum Pathol 2011;42:817), pancreatic endocrine cells (Appl Immunohistochem Mol Morphol 2009;17:413)

Positive staining - disease

GIST, pancreatic solid-pseudopapillary neoplasm (Hum Pathol 2011;42:817)
Often esophageal squamous cell and gastric carcinomas
- Occasionally uterine type retroperitoneal leiomyomas colonized by DOG1+ Cajal cells, peritoneal leiomyomatosis, synovial sarcomas (Am J Surg Pathol 2009;33:1401)