Author: Nat Pernick, M.D. (see Authors page)

Revised: 8 December 2015, last major update November 2011

Copyright: (c) 2002-2015,, Inc.

PubMed Search: DOG1 [title]

Cite this page: DOG1. website. Accessed October 22nd, 2018.
Definition / general
  • Discovered On GIST 1
  • Chloride channel protein
  • Membranous and cytoplasmic staining
Uses by pathologists
Microscopic (histologic) images

Images hosted on Other servers:

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GIST: p16, DOG1 and PDGFRA

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GIST and other tumors

Positive staining - normal
Positive staining - disease
  • GIST, pancreatic solid-pseudopapillary neoplasm (Hum Pathol 2011;42:817)
  • Often esophageal squamous cell and gastric carcinomas
    • Occasionally uterine type retroperitoneal leiomyomas colonized by DOG1+ Cajal cells, peritoneal leiomyomatosis, synovial sarcomas (Am J Surg Pathol 2009;33:1401)