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Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 20 November 2011, last major update November 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.


Discovered On GIST 1
● Chloride channel protein


● Membranous and cytoplasmic staining

Uses for Pathologists

● (1) Sensitive and specific marker for GIST (Gut Liver 2011;5:171)
● (2) May be more sensitive and specific for GIST than CD117/KIT in cell blocks (Cancer Cytopathol 2011;119:202, Am J Clin Pathol 2011;135:448)
● (3) Sensitive for CD117 negative GIST tumor (non-GI tumors are usually DOG1+, Am J Surg Pathol 2011;35:1287, Mod Pathol 2011;24:866)
● (4) Negative staining suggests tumor is not GIST (Cancer Control 2011;18:152)
● (5) Distinguish gastric plexiform fibromyxoma (alpha smooth muscle actin+, KIT-, DOG1-, CD34-, no KIT/PDGFRA mutations) from GIST (opposite, Am J Surg Pathol 2009;33:1624)
● (6) Marker for interstitial cells of Cajal in GI tract

Micro images


GIST: p16, DOG1 and PDGFRA

GIST and other tumors: DOG1 and KIT immunohistochemistry and in-situ hypbridization

Positive stains - normal

● Gastric epithelium, interstitial cells of Cajal, pancreatic centroacinar cells (Hum Pathol 2011;42:817), pancreatic endocrine cells (Appl Immunohistochem Mol Morphol 2009;17:413)

Positive staining - tumors

● GIST, pancreatic solid-pseudopapillary neoplasm (Hum Pathol 2011;42:817)
● Often esophageal squamous cell and gastric carcinomas; occasionally uterine type retroperitoneal leiomyomas colonized by DOG1+ Cajal cells, peritoneal leiomyomatosis, synovial sarcomas (Am J Surg Pathol 2009;33:1401)

End of Stains > DOG1

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