Stains
ERG

Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 December 2015, last major update November 2012

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: ERG [title]

Cite this page: ERG. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsERG.html. Accessed December 5th, 2016.
Definition / General
  • Transcription factor highly specific and 50% sensitive for prostatic adenocarcinoma
  • Detect via FISH or immunohistochemistry
Terminology
  • V-ets erythroblastosis virus E26 oncogen homologue
  • ETS family transcription factor present at 22q12
Uses by Pathologists
Diagrams / Tables
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TMPRSS2:ERG gene rearrangements

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ERG rearrangement

Clinical Features
Micro Images

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Prostate, adenocarcinoma

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Prostate, small cell carcinoma

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Prostate needle biopsies

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Prostatectomy specimens

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HGPIN



Nature images:

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Small foci, prostate cancer

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Prostate, high grade PIN

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Prostate, adenocarcinoma

Positive Staining - Normal
  • Endothelial cells, some bone marrow precursors
  • Also early fetal mesenchyme and subpopulations of fetal cartilage (Am J Surg Pathol 2011;35:432)
Positive Staining - Disease
Negative Staining
  • Benign prostatic glands distant from adenocarcinoma
  • Most other carcinomas and epitheliod tumors (Mod Pathol 2010;23:1061)
Molecular / Cytogenetics Images

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Prostatic adenocarcinoma (FISH)

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Prostatic small cell carcinoma, FISH for ERG



Nature images:

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Prostatic adenocarcinoma (FISH)