Topic Completed: 1 November 2012

Revised: 5 March 2019

Copyright: 2002-2018,, Inc.

PubMed Search: ERG [title] stain
Page views in 2018: 6,819
Page views in 2019 to date: 562
Cite this page: Pernick N. ERG. website. Accessed March 20th, 2019.
Definition / general
  • Transcription factor highly specific and 50% sensitive for prostatic adenocarcinoma
  • Detect via FISH or immunohistochemistry
  • V-ets erythroblastosis virus E26 oncogen homologue
  • ETS family transcription factor present at 22q12
Uses by pathologists
Diagrams / tables

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TMPRSS2:ERG gene rearrangements

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ERG rearrangement

Clinical features
Microscopic (histologic) images

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Contributed by Debra Zynger M.D.

Lymphovascular invasion (pT2)

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Prostate, adenocarcinoma

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Prostate, small cell carcinoma

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Prostate needle biopsies

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Prostatectomy specimens

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Positive staining - normal
  • Endothelial cells, some bone marrow precursors
  • Also early fetal mesenchyme and subpopulations of fetal cartilage (Am J Surg Pathol 2011;35:432)
Positive staining - disease
Negative staining
  • Benign prostatic glands distant from adenocarcinoma
  • Most other carcinomas and epitheliod tumors (Mod Pathol 2010;23:1061)
Molecular / cytogenetics images

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Prostatic adenocarcinoma (FISH)

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Prostatic small cell carcinoma, FISH for ERG

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