Author: Kara Hamilton, M.S., Nat Pernick, M.D. (see Authors page)

Revised: 24 November 2015, last major update July 2009

Copyright: (c) 2002-2015,, Inc.

Cite this page: HE4. website. Accessed May 21st, 2018.
Definition / general
  • Antibody against Human Epididymis protein 4, a protease inhibitor
  • Also called WAP5 and WFDC2 (WAP four-disulfide core domain 2)
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Respiratory tract and salivary glands

Cystic fibrosis of lung

Major and minor glands (Fig B, E)

Pulmonary neoplasms

Ovarian carcinoma-various subtypes

Images hosted on

Various tumors

Positive staining - normal
  • Breast (female)
  • Colonic mucosa
  • Epididymis (Biol Reprod 1991;45:350) and vas deferens
  • Female genital tract (endocervix, endometrium, fallopian tube, ovary)
  • Renal tubules
  • Respiratory epithelium
  • Salivary glands
Positive staining - disease
Negative staining
  • Most non-ovarian carcinomas