Author: Kara Hamilton, M.S., Nat Pernick, M.D. (see Authors page)

Revised: 24 November 2015, last major update July 2009

Copyright: (c) 2002-2015,, Inc.

Cite this page: HE4. website. Accessed April 24th, 2017.
Definition / General
  • Antibody against Human Epididymis protein 4, a protease inhibitor
  • Also called WAP5 and WFDC2 (WAP four-disulfide core domain 2)
Uses by Pathologists
Micro Images

Images hosted on other servers:

Respiratory tract and salivary glands

Cystic fibrosis of lung

Major and minor glands (Fig B, E)

Pulmonary neoplasms

Ovarian carcinoma-various subtypes

Images hosted on

Various tumors

Positive Staining - Normal
  • Breast (female)
  • Colonic mucosa
  • Epididymis (Biol Reprod 1991;45:350) and vas deferens
  • Female genital tract (endocervix, endometrium, fallopian tube, ovary)
  • Renal tubules
  • Respiratory epithelium
  • Salivary glands
Positive Staining - Disease
Negative Staining
  • Most non-ovarian carcinomas