Stains & molecular markers

Topic Completed: 1 November 2011

Minor changes: 18 September 2020

Copyright: 2002-2020,, Inc.

PubMed Search: HGAL [title]

Nat Pernick, M.D.
Page views in 2019: 657
Page views in 2020 to date: 539
Cite this page: Pernick N. HGAL. website. Accessed September 20th, 2020.
Definition / general
  • Human germinal center-associated lymphoma; also called germinal center B-cell expressed transcript 2
  • NOT human-galectin
  • Inhibits lymphocyte and lymphoma cell motility by activating the RhoA signaling cascade (Blood 2010;116:5217)
  • Also interacts with actin and myosin proteins and reduces the maximum velocity of myosin head / actin movement (FEBS J 2011;278:1922)
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:
Missing Image

Normal tonsil

Missing Image Missing Image Missing Image Missing Image

Follicular neoplasms

Missing Image


Missing Image Missing Image

Classical Hodgkin lymphoma

Positive staining - normal
  • Germinal center lymphocytes
Positive staining - disease
  • Germinal center derived lymphomas, including follicular center cell lymphoma
Back to top
Image 01 Image 02