Topic Completed: 1 November 2011

Minor changes: 6 March 2019

Copyright: 2002-2015,, Inc.

PubMed Search: HGAL [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. HGAL. website. Accessed June 1st, 2020.
Definition / general
  • Human germinal center-associated lymphoma; also called germinal center B-cell expressed transcript 2
  • NOT human-galectin
  • Inhibits lymphocyte and lymphoma cell motility by activating the RhoA signaling cascade (Blood 2010;116:5217)
  • Also interacts with actin and myosin proteins and reduces the maximum velocity of myosin head / actin movement (FEBS J 2011;278:1922)
Uses by pathologists
Microscopic (histologic) images

Images hosted on Other servers:

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Normal tonsil

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Follicular neoplasms

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Classical Hodgkin lymphoma

Positive staining - normal
  • Germinal center lymphocytes
Positive staining - disease
  • Germinal center derived lymphomas, including follicular center cell lymphoma
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