Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 21 November 2011, last major update November 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
● Human germinal center-associated lymphoma; also called germinal center B-cell expressed transcript 2
● NOT human-galectin
● Inhibits lymphocyte and lymphoma cell motility by activating the RhoA signaling cascade (Blood 2010;116:5217); also interacts with actin and myosin proteins and reduces the maximum velocity of myosin head / actin movement (FEBS J 2011;278:1922)
Uses by Pathologists
● (1) More sensitive for follicular lymphoma than bcl6 and CD10 (Diagn Pathol 2011;6:97), and particularly helpful in detecting its interfollicular and diffuse components (Am J Surg Pathol 2010;34:1266)
● (2) Favorable marker in diffuse large B cell lymphoma (Blood 2003;101:433) and classical Hodgkin lymphoma (Leuk Lymphoma 2009;50:1830, Blood 2007;109:298)
● (3) Help classify cutaneous large B-cell lymphomas (Mod Pathol 2008;21:653)
Nodal marginal zone lymphoma versus follicular lymphoma
Diffuse large B cell lymphoma versus primary cutaneous follicular center cell lymphoma
Classical Hodgkin lymphoma
Positive stains - normal
● Germinal center lymphocytes
Positive stains - tumors
● Germinal center derived lymphomas, including follicular center cell lymphoma
End of Stains > HGAL
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