Stains
HGAL

Author: Nat Pernick, M.D. (see Authors page)

Revised: 1 December 2015, last major update November 2011

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: HGAL [title]

Definition / General
  • Human germinal center-associated lymphoma; also called germinal center B-cell expressed transcript 2
  • NOT human-galectin
Pathophysiology
  • Inhibits lymphocyte and lymphoma cell motility by activating the RhoA signaling cascade (Blood 2010;116:5217)
  • Also interacts with actin and myosin proteins and reduces the maximum velocity of myosin head / actin movement (FEBS J 2011;278:1922)
Uses by Pathologists
Micro Images

Images hosted on Other servers:

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Normal tonsil

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Follicular neoplasms

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NMZL

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Classical Hodgkin lymphoma

Positive Staining - Normal
  • Germinal center lymphocytes
Positive Staining - Disease
  • Germinal center derived lymphomas, including follicular center cell lymphoma