Cite this page: A beta 42. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsabeta42.html. Accessed February 20th, 2017.
Definition / General
- Aβ42 is generated by sequential processing of β-amyloid precursor protein (APP) by beta and gamma secretase, which likely has a causative role in Alzheimer's disease (AD)
- Aβ42 is main constituent of amyloid plaque in brains of patients with Alzheimer disease; has 2 common isoforms: Aβ40 is more common, Aβ42 is more amyloidogenic and may lead to formation of plaques (Alzheimers Res Ther 2012;4:9)
- Production of Aβ42 is enhanced by familial AD mutations in presenilin 1 (PS1) and PS2, as well as by some familial AD mutations in APP (J Biol Chem 2011;286:15240)