A beta 42

Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 November 2015, last major update uly 2015

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Abeta42[title]
  • Aβ42 is generated by sequential processing of β-amyloid precursor protein (APP) by beta and gamma secretase, which likely has a causative role in Alzheimer's disease (AD)
  • Aβ42 is main constituent of amyloid plaque in brains of patients with Alzheimer disease; has 2 common isoforms: Aβ40 is more common, Aβ42 is more amyloidogenic and may lead to formation of plaques (Alzheimers Res Ther 2012;4:9)
  • Production of Aβ42 is enhanced by familial AD mutations in presenilin 1 (PS1) and PS2, as well as by some familial AD mutations in APP (J Biol Chem 2011;286:15240)
Clinical Features

    Apolipoprotein E / Aβ interaction pathways
    and therapeutic approaches

Micro Images

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Brain tissue of Alzheimer's disease patient

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Copper abolishes the negatively-stained fibrillar structure

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Incremental changes to
structure of amyloid