Stains - A beta 42

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Stains

A beta 42

Reviewer: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 20 April 2011, last major update April 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Physiology
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● Sequential processing of the beta-amyloid precursor protein (APP) by beta and gamma secretase generates the amyloid beta-peptide (A beta), which likely has a causative role in Alzheimer's disease (AD)
● A beta 42 is a 42 amino acid variant of A beta, believed to be pathogenic
● A beta 42 may trigger the amyloid cascade, leading to formation of plaques
● A beta 42 is usually a minor species produced by APP cleavage, but its production is enhanced by familial Alzheimer Disease mutations in presenilin 1 (PS1) and PS2, as well as by some familial Alzheimer Disease mutations in APP (J Biol Chem 2011 Feb 25 [Epub ahead of print])

End of Stains > A beta 42

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