A beta 42

Topic Completed: 1 July 2015

Revised: 4 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: Abeta42[title]

Nat Pernick, M.D.
Page views in 2018: 145
Page views in 2019 to date: 129
Cite this page: Pernick N. A beta 42. website. Accessed September 16th, 2019.
Definition / general
  • Aβ42 is generated by sequential processing of β-amyloid precursor protein (APP) by beta and gamma secretase, which likely has a causative role in Alzheimer's disease (AD)
  • Aβ42 is main constituent of amyloid plaque in brains of patients with Alzheimer disease; has 2 common isoforms: Aβ40 is more common, Aβ42 is more amyloidogenic and may lead to formation of plaques (Alzheimers Res Ther 2012;4:9)
  • Production of Aβ42 is enhanced by familial AD mutations in presenilin 1 (PS1) and PS2, as well as by some familial AD mutations in APP (J Biol Chem 2011;286:15240)
Clinical features
Diagrams / tables

    Apolipoprotein E / Aβ interaction pathways
    and therapeutic approaches

Microscopic (histologic) images

Images hosted on other servers:

Brain tissue of Alzheimer's disease patient

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