A beta 42
Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 11 August 2013, last major update August 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
PubMed Search: Abeta42[title]
General / Pathophysiology
- Aβ is generated by sequential processing of β-amyloid precursor protein (APP) by beta and gamma secretase, which likely has a causative role in Alzheimer's disease (AD)
- Aβ is main constituent of amyloid plaque in brains of patients with Alzheimer disease; has 2 common isoforms: Aβ40 is more common, Aβ42 is more amyloidogenic and may lead to formation of plaques (Alzheimers Res Ther 2012;4:9)
- Production of Aβ42 is enhanced by familial AD mutations in presenilin 1 (PS1) and PS2, as well as by some familial AD mutations in APP (J Biol Chem 2011;286:15240)
Apolipoprotein E / Aβ interaction pathways and therapeutic approaches
Copper abolishes the negatively-stained fibrillar structure
Incremental changes to structure of amyloid deposits
End of Stains > A beta 42
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com
with any questions (click here for other