Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 November 2015, last major update July 2015

Copyright: (c) 2003-2015,, Inc.

PubMed Search: ABL[title]
Cite this page: ABL. website. Accessed October 25th, 2016.
Definition / General
  • Also called c-abl
  • Gene at 9q34.1, named after ABelson murine Leukemia virus
  • Abelson family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces diverse extracellular signals to protein networks that control proliferation, survival, migration and invasion (Nat Rev Cancer 2013;13:559)
  • Dysregulated tyrosine kinase activates a network of signals that contributes to cytokine independent growth, resistance to apoptosis and genetic instability (Cancer Control 2009;16:100)
  • Also regulates BMP2 induced osteogenesis (J Biol Chem 2013;288:24503)
Clinical Features
Diagrams / Tables


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Liver: Hepatocellular carcinoma