Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 11 August 2013, last major update August 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
PubMed Search: ABL[title]
- Also called c-abl
- Gene at 9q34.1, named after ABelson murine Leukemia virus
- Abelson family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces diverse extracellular signals to protein networks that control proliferation, survival, migration and invasion (Nat Rev Cancer 2013;13:559)
- Dysregulated tyrosine kinase activates a network of signals that contributes to cytokine independent growth, resistance to apoptosis and genetic instability (Cancer Control 2009;16:100)
- Also regulates BMP2 induced osteogenesis (J Biol Chem 2013 Jul 2 [Epub ahead of print])
Liver: Hepatocellular carcinoma
End of Stains > ABL
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