Topic Completed: 1 July 2015

Revised: 4 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: ABL[title]

Nat Pernick, M.D.
Page views in 2018: 59
Page views in 2019 to date: 73
Cite this page: Pernick N. ABL. website. Accessed September 22nd, 2019.
Definition / general
  • Also called c-abl
  • Gene at 9q34.1, named after ABelson murine Leukemia virus
  • Abelson family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces diverse extracellular signals to protein networks that control proliferation, survival, migration and invasion (Nat Rev Cancer 2013;13:559)
  • Dysregulated tyrosine kinase activates a network of signals that contributes to cytokine independent growth, resistance to apoptosis and genetic instability (Cancer Control 2009;16:100)
  • Also regulates BMP2 induced osteogenesis (J Biol Chem 2013;288:24503)
Clinical features
Diagrams / tables


Microscopic (histologic) images

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Liver: Hepatocellular carcinoma

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