Stains - abl

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Stains

abl

Reviewer: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 6 February 2012, last major update April 2011
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

Definition
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● Also called c-abl
● Gene at 9q34.1, named after ABelson murine Leukemia virus
● Functions as a tyrosine kinase / signal transducer and a negative regulator of apoptosis
● Dysregulated tyrosine kinase activates a network of signals that contributes to cytokine-independent growth, resistance to apoptosis and genetic instability (Cancer Control 2009;16:100)
● Commonly overexpressed in chronic myelogenous leukemia (CML), due to t(9;22)(q34;q11), the Philadelphia chromosome, which produces the BCR-ABL fusion gene; BCR-ABL transcript can be demonstrated with RT-PCR
● Also occurs in Philadelphia chromosome-positive acute myeloid leukemia (a rare aggressive leukemia distinct from CML in blast crisis, Am J Clin Pathol 2007;127:642) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Hematology Am Soc Hematol Educ Program 2009:371)
● Inhibited by imatinib mesylate (Gleevec, STI571), a treatment for CML

Diagrams
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t(9;22)

End of Stains > abl

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