Acid phosphatase

Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 November 2015, last major update August 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Acid phosphatase[title]
Clinical Features
  • Higher serum acid phosphatase in malaria patients (Indian J Clin Biochem 2011;26:396)
  • Acid phosphatase locus 1 allele:
    • Produced by erythrocytes, encodes low molecular weight phosphotyrosine phosphatase
    • Genetically polymorphic; three common alleles segregating at corresponding locus give rise to six phenotypes (Wikipedia)
    • Associated with systemic lupus erythematosus (Hum Immunol 2012;73:107)
Micro Images

Images hosted on Pathout server:

Pre-T ALL: focal
paranuclear staining

Images hosted on other servers:

Skeletal muscle: immune myopathies with perimysial pathology

Skeletal muscle: perimysial inflammation in dermatomyositis

Skeletal muscle: necrotic muscle in dermatomyositis

Positive Staining - Normal
Positive Staining - Disease