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Stains
Acid phosphatase
Reviewer: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers
page)
Revised: 21 April 2012, last major update April 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
General
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● Class of enzymes that releases phosphate groups, optimally at acid pH
● Usually detected with enzyme histochemistry technique
● Examples include PAP-prostatic acid phosphatase and TRAP-tartrate resistant acid phosphatase
● Also useful for examining skeletal muscle pathology
Micro images
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Mature megakaryocytes and macrophages
Immune myopathies with perimysial pathology: perimysial cells
Dermatomyositis-variant adult pattern: acid phosphatase stains cells in necrotic muscle fibers
Pre-T ALL: focal paranuclear staining
Positive staining - normal
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● Osteoclasts, megakaryocytes, macrophages
Positive staining - disease
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● Osteoclastic giant cells in tumors
● T-ALL (focal paranuclear), acute basophilic leukemia, granular cell tumor
● AML (variable)
Additional references
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End of Stains > Acid phosphatase
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