Stains
Acid phosphatase

Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 November 2015, last major update August 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: Acid phosphatase[title]
Cite this page: Acid phosphatase. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsacidphosphatase.html. Accessed August 22nd, 2017.
Definition / general
Clinical features
  • Higher serum acid phosphatase in malaria patients (Indian J Clin Biochem 2011;26:396)
  • Acid phosphatase locus 1 allele:
    • Produced by erythrocytes, encodes low molecular weight phosphotyrosine phosphatase
    • Genetically polymorphic; three common alleles segregating at corresponding locus give rise to six phenotypes (Wikipedia)
    • Associated with systemic lupus erythematosus (Hum Immunol 2012;73:107)
Microscopic (histologic) images

Images hosted on Pathout server:

Pre-T ALL: focal
paranuclear staining



Images hosted on other servers:

Skeletal muscle: immune myopathies with perimysial pathology

Skeletal muscle: perimysial inflammation in dermatomyositis

Skeletal muscle: necrotic muscle in dermatomyositis


Positive staining - normal
Positive staining - disease