Reviewer: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 24 April 2011, last major update April 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
(1) To identify small numbers of bacteria and microorganisms under fluorescent light, including mycobacteria (Indian J Pathol Microbiol 2010;53:894) and malaria parasites (Ann Trop Med Parasitol 2002;96:643)
(2) In fertility testing, is part of sperm chromatin structural assay, which reflects sperm chromatin denaturation (J Assist Reprod Genet 2009;26:591)
(3) Part of photodynamic therapy to treat musculoskeletal sarcoma (J Bone Joint Surg Br 2010;92:760)
(4) To identify engulfed apoptotic cells, because it fluoresences upon engulfment
● Cell-permeable, interacts with DNA by intercalation and with RNA by electrostatic attraction
Fluoresent staining of mycobacteria
Fluorescent staining of trypanosomes and some platelets
Staining of chromatin in sperm of man with history of recurrent spontaneous abortion in partner
End of Stains > Acridine orange
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