Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 2 January 2012, last major update January 2012
Copyright: (c) 2012, PathologyOutlines.com, Inc.
● First discovered in 2001, also called MACS1 (J Biol Chem 2001;276:35961)
● Also called acyl-CoA synthetase medium-chain family member 1 (Mol Cell Proteomics 2008;7:1795); encodes for enzyme catalyzing the activation of medium-chain length fatty acids
● Breast apocrine marker; also a schizophrenia susceptibility gene (J Psychiatr Res 2010;44:748)
Uses by pathologists
● Marker of apocrine breast lesions (benign and malignant)
Various normal tissues
Benign breast apocrine lesions
Invasive breast apocrine carcinoma
Positive staining - normal
Positive staining - disease
● Breast: benign and malignant apocrine lesions (Mol Oncol 2009;3:220)
End of Stains > ACSM1
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