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Stains

ACSM1

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 2 January 2012, last major update January 2012
Copyright: (c) 2012, PathologyOutlines.com, Inc.

Definition
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● First discovered in 2001, also called MACS1 (J Biol Chem 2001;276:35961)
● Also called acyl-CoA synthetase medium-chain family member 1 (Mol Cell Proteomics 2008;7:1795); encodes for enzyme catalyzing the activation of medium-chain length fatty acids
● Breast apocrine marker; also a schizophrenia susceptibility gene (J Psychiatr Res 2010;44:748)

Uses by pathologists
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● Marker of apocrine breast lesions (benign and malignant)

Micro images
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Various normal tissues


Benign breast apocrine lesions


Invasive breast apocrine carcinoma

Positive staining - normal
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● Esophagus

Positive staining - disease
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● Breast: benign and malignant apocrine lesions (Mol Oncol 2009;3:220)

End of Stains > ACSM1

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