Topic Completed: 1 September 2013

Minor changes: 4 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: ACSM1, Acyl-CoA synthetase medium chain family member 1

Nat Pernick, M.D.
Page views in 2019: 35
Page views in 2020 to date: 17
Cite this page: Pernick N. ACSM1. website. Accessed June 4th, 2020.
Definition / general
  • First discovered in 2001, also called MACS1 (J Biol Chem 2001;276:35961), acyl-CoA synthetase medium-chain family member 1
  • Encodes enzyme catalyzing activation of medium chain length fatty acids (OMIM #614357)
  • Present on chromosome 16p12-13
Clinical features
Uses by pathologists
  • Marker of apocrine breast lesions (benign and malignant)
Microscopic (histologic) images

Images hosted on other servers:

Various normal tissues

Benign breast apocrine lesions

Invasive breast apocrine carcinoma

Kidney tubules (second image in slideshow)

Positive staining - normal
Positive staining - disease
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