Cytokeratin AE3

Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 December 2015, last major update October 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: AE3[title]
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Cite this page: Cytokeratin AE3. website. Accessed January 22nd, 2019.
Definition / general
  • Often used in a cytokeratin cocktail with AE1 (see AE1/AE3)
  • Detects high molecular weight CK1, 2, 3, 4, 5 and CK6 and low molecular weight CK7 and CK8; these are basic (type II) cytokeratins
  • Often considered a high molecular weight antibody (CK1-CK6 are high molecular weight, CK7-CK8 are low molecular weight)
  • Another high molecular weight keratin is 34 beta E12
  • Caution: AE3 is also the name of a chloride/bicarbonate anion exchanger (Biochem J 2003;371:687)
Positive staining - normal
Positive staining - disease
Microscopic (histologic) images

Nodal reticulum cells