Cytokeratin AE3

Topic Completed: 1 October 2013

Revised: 5 March 2019

Copyright: 2003-2015,, Inc.

PubMed Search: AE3[title]

Nat Pernick, M.D.
Page views in 2018: 401
Page views in 2019 to date: 319
Cite this page: Pernick N. Cytokeratin AE3. website. Accessed September 18th, 2019.
Definition / general
  • Often used in a cytokeratin cocktail with AE1 (see AE1/AE3)
  • Detects high molecular weight CK1, 2, 3, 4, 5 and CK6 and low molecular weight CK7 and CK8; these are basic (type II) cytokeratins
  • Often considered a high molecular weight antibody (CK1-CK6 are high molecular weight, CK7-CK8 are low molecular weight)
  • Another high molecular weight keratin is 34 beta E12
  • Caution: AE3 is also the name of a chloride/bicarbonate anion exchanger (Biochem J 2003;371:687)
Positive staining - normal
Positive staining - disease
Microscopic (histologic) images

Nodal reticulum cells

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