Topic Completed: 1 August 2013

Revised: 4 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: AGR2

Nat Pernick, M.D.
Page views in 2018: 24
Page views in 2019 to date: 26
Cite this page: Pernick N. AGR2. website. Accessed September 23rd, 2019.
Definition / general
  • Anterior gradient protein 2
  • Member of protein disulfide isomerase family; homolog of African clawed frog (Xenopus laevis) gene XAG2
  • Secreted peptide known to promote cell metastasis (Exp Cell Res 2012;318:1788, Exp Mol Med 2011;43:91)
  • Localizes in endoplasmic reticulum of normal intestinal epithelial cells and is essential for in vivo production of mucus; mediates processing of MUC2 through formation of mixed disulfide bonds (Cancer Res 2011;71:7091)
Clinical features
Microscopic (histologic) images

Esophagus: adenocarcinoma

Ovary: mucinous carcinoma

Pancreas: normal and malignant

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