Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 11 August 2013, last major update August 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
PubMed Search: AGR2
- Anterior gradient protein 2
- Member of protein disulfide isomerase family; homolog of African clawed frog (Xenopus laevis) gene XAG-2
- Secreted peptide known to promote cell metastasis (Exp Cell Res 2012;318:1788, Exp Mol Med 2011;43:91)
- Localizes in endoplasmic reticulum of normal intestinal epithelial cells and is essential for in vivo production of mucus; mediates processing of MUC2 through formation of mixed disulfide bonds (Cancer Res 2011;71:7091)
Bone and soft tissue metastases
Breast: normal and carcinoma
Ovary: mucinous carcinoma
Pancreas: normal and malignant
End of Stains > AGR2
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com
with any questions (click here for other