Author: Author: Nat Pernick, M.D.

Revised: 21 March 2018, last major update August 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: AGR2
Cite this page: Pernick, N. AGR2. website. Accessed March 23rd, 2018.
Definition / general
  • Anterior gradient protein 2
  • Member of protein disulfide isomerase family; homolog of African clawed frog (Xenopus laevis) gene XAG2
  • Secreted peptide known to promote cell metastasis (Exp Cell Res 2012;318:1788, Exp Mol Med 2011;43:91)
  • Localizes in endoplasmic reticulum of normal intestinal epithelial cells and is essential for in vivo production of mucus; mediates processing of MUC2 through formation of mixed disulfide bonds (Cancer Res 2011;71:7091)
Clinical features
Microscopic (histologic) images

Esophagus: adenocarcinoma

Ovary: mucinous carcinoma

Pancreas: normal and malignant