Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 September 2015, last major update July 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Akt1+[title]
  • AKT1 is a serine / threonine protein kinase
  • Also called RAC-alpha serine / threonine-protein kinase, v-akt murine-thymoma viral-oncogene-homolog 1, protein kinase B (PKB)
  • Encoded by AKT1 gene
  • Regulates many processes including metabolism, proliferation, cell survival, growth and angiogenesis (UniProt, Wikipedia)
  • Activation, a frequence alteration in cancer, occurs through phosphatidylinositol 3-kinase, and pathway may also include PTEN, KRAS and mTOR
Clinical Features

PI3K-AKT pathway

Micro Images

Abnormal epidermal stratification

Head and neck squamous cell carcinoma (fig 5C)

Missing Image

Intrahepatic cholangio- carcinoma (fig B)

Oral squamous cell carcinoma (fig 1)

Pancreatic tumors (fig 1)

Phospho-specific AKT antibody

Phosphorylation levels of Akt with NBS1

Positive Staining - Normal